Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine) polymer layer on Co-Cr-Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage.

Kyomoto M; Moro T; Saiga

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Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine) polymer layer on Co-Cr-Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage.

机译：Co-Cr-Mo表面的聚（2-甲基丙烯酰氧基乙基磷酰胆碱）聚合物层的润滑性和稳定性，用于半关节置换术以防止关节软骨变性。

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Migration of the artificial femoral head to the inside of the pelvis due to the degeneration of acetabular cartilage has emerged as a serious issue in resurfacing or bipolar hemi-arthroplasty. Surface modification of cobalt-chromium-molybdenum alloy (Co-Cr-Mo) is one of the promising means of improving lubrication for preventing the migration of the artificial femoral head. In this study, we systematically investigated the surface properties, such as lubricity, biocompatibility, and stability of the various modification layers formed on the Co-Cr-Mo with the biocompatible 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer by dip coating or grafting. The cartilage/poly(MPC) (PMPC)-grafted Co-Cr-Mo interface, which mimicked a natural joint, showed an extremely low friction coefficient of <0.01, as low as that of a natural cartilage interface. Moreover, the long-term stability in water was confirmed for the PMPC-grafted layer; no hydrolysis of the siloxane bond was observed throughout soaking in phosphate-buffered saline for 12 weeks. The PMPC-grafted Co-Cr-Mo femoral head for hemi-arthroplasty is a promising option for preserving acetabular cartilage and extending the duration before total hip arthroplasty.

机译：由于髋臼软骨退化引起的人工股骨头向骨盆内部的迁移已成为表面置换术或双极半髋置换术中的一个严重问题。钴铬钼合金（Co-Cr-Mo）的表面改性是改善润滑性以防止人工股骨头迁移的一种有前途的手段。在这项研究中，我们系统地研究了通过浸涂或接枝与生物相容性2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）聚合物在Co-Cr-Mo上形成的各种改性层的表面性能，如润滑性，生物相容性和稳定性。模仿天然关节的软骨/聚（MPC）（PMPC）接枝的Co-Cr-Mo界面显示了<0.01的极低摩擦系数，与天然软骨界面一样低。而且，证实了PMPC接枝层在水中的长期稳定性。在磷酸盐缓冲液中浸泡12周未观察到硅氧烷键的水解。 PMPC移植的Co-Cr-Mo股骨头用于半髋关节置换术是保留髋臼软骨并延长全髋关节置换术前持续时间的有前途的选择。

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《Biomaterials》 |2010年第4期|共11页
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Kyomoto M; Moro T; Saiga;
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中图分类医用一般科学;
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1. Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine) polymer layer on Co-Cr-Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage. [J] . Kyomoto M, Moro T, Saiga Biomaterials . 2010,第4期

机译：Co-Cr-Mo表面的聚（2-甲基丙烯酰氧基乙基磷酰胆碱）聚合物层的润滑性和稳定性，用于半关节置换术以防止关节软骨变性。
2. Preparation of a thick polymer brush layer composed of poly(2-methacryloyloxyethyl phosphorylcholine) by surface-initiated atom transfer radical polymerization and analysis of protein adsorption resistance [J] . Inoue Yuuki, Onodera Yuya, Ishihara Kazuhiko Colloids and Surfaces, B. Biointerfaces . 2016,第Null期

机译：通过表面引发的原子转移自由基聚合制备由聚（2-甲基丙烯酰氧基氧乙基磷酸胆碱）组成的厚聚合物刷层，并分析其蛋白质吸附性
3. High-efficiency preparation of poly(2-methacryloyloxyethyl phosphorylcholine) grafting layer on poly(ether ether ketone) by photoinduced and self-initiated graft polymerization in an aqueous solution in the presence of inorganic salt additives [J] . Shiojima Taro, Inoue Yuuki, Kyomoto Masayuki, Acta biomaterialia . 2016,第Null期

机译：在无机盐添加剂存在下，在水溶液中通过光诱导和自引发接枝聚合高效制备聚醚醚酮上的聚2-甲基丙烯酰氧基氧基乙基磷酸胆碱接枝层
4. Antithrombogenic Surface on Poly(ether ether ketone) Prepared by Self-initiated Photoinduced Graft Polymerization of 2-Methacryloyloxyethyl Phosphorylcholine [C] . Kazuhiko Ishihara, Masayuki Kyomoto, Tetsuji Yamaoka, European conference on biomaterials . 2014

机译：通过自引发的2-甲基丙烯酰氧基氧乙基磷酸胆碱的光引发接枝聚合反应制备聚醚醚酮上的抗血栓形成表面
5. The synthesis and surface analysis of phosphorylcholine-terminated poly(dimethylsiloxane)s and self-assembled monolayers. [D] . Cameron, Ryan Bradley. 1998

机译：磷酸胆碱封端的聚二甲基硅氧烷和自组装单分子膜的合成和表面分析。
6. Cryoscanning electron microscopic study of the surface amorphous layer of articular cartilage. [O] . S Kobayashi, S Yonekubo, Y Kurogouchi 1995

机译：关节软骨表面无定形层的低温扫描电子显微镜研究。
7. Synthesis, characterisation, and in vitro cellular uptake kinetics of nanoprecipitated poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(2-(diisopropylamino)ethyl methacrylate) (MPC-DPA) polymeric nanoparticle micelles for nanomedicine applications [O] . Salvage, Jonathan, Smith, Tia, Lu, Tao, 2016

机译：纳米沉淀的聚（2-甲基丙烯酰氧基乙基磷酰胆碱）-b-聚（甲基丙烯酸2-（二异丙基氨基）乙酯）（MPC-DPA）高分子纳米胶束的合成，表征和体外细胞吸收动力学，用于纳米医学

Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine) polymer layer on Co-Cr-Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage.

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