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首页> 外文期刊>Spinal cord: the official journal of the International Medical Society of Paraplegia >The prevalence of small intestinal bacterial overgrowth and methane production in patients with myelomeningocele and constipation
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The prevalence of small intestinal bacterial overgrowth and methane production in patients with myelomeningocele and constipation

机译：小肠脑膜膨出和便秘患者小肠细菌过度生长和甲烷生成的患病率

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Study design:Prospective study.Objectives:The objective of this study was to assess the prevalence of small intestinal bacterial overgrowth (SIBO), methane (CH 4) production and orocecal transit time (OCTT) in children affected by myelomeningocele.Setting:This study was conducted at the Catholic University in Rome, Italy.Methods:Eighteen (6M/12F; 16.4±7.6 years) children affected by myelomeningocele were enrolled. All subjects underwent H 2 /CH 4 lactulose breath tests to assess SIBO and OCTT. All patients performed a visual analog scale to investigate abdominal pain, bloating and flatulence, and maintained a diary of the frequency and consistency of the stool during the previous 7 days. A nephro-urological clinical evaluation of the number of urinary tract infections (UTIs) and neurogenic bowel disease score were also performed.Results:Thirty-nine percent (7/18) of the children showed SIBO and 61% (11/18) presented a delayed OCTT. Moreover 44.4% (8/18) produced high levels of CH 4. Interestingly, all myelomeningocele children who produced CH 4 showed a delayed OCTT and a higher incidence of UTI, with a lower frequency of evacuation, compared with those with a normal or accelerated OCTT.Conclusion:The association between CH 4 and constipation suggests that CH 4 has an active role in the development of constipation. One of the most interesting features of our study is to identify a correlation between myelomeningocele, CH 4, delayed OCTT and UTI. The intestinal decontamination with locally acting drugs in these children may reduce the number of UTIs and improve intestinal motility.
机译：研究设计：前瞻性研究。目的：本研究的目的是评估脊髓膜脑膨出患儿小肠细菌过度生长（SIBO），甲烷（CH 4）产生和口经时间（OCTT）的发生率。方法：在意大利罗马的天主教大学进行研究。方法：招募十八名（6M / 12F; 16.4±7.6岁）受髓鞘膜膨出症影响的儿童。所有受试者均接受H 2 / CH 4乳果糖呼气试验以评估SIBO和OCTT。所有患者均进行了视觉模拟评分，以调查腹痛，腹胀和肠胃气胀，并在前7天保持了大便次数和稠度的日记。还进行了肾泌尿外科临床评估，评估了尿路感染（UTI）数量和神经源性肠道疾病评分。结果：三十九％（7/18）的儿童表现为SIBO，61％（11/18）表现为儿童延迟的OCTT。此外，有44.4％（8/18）的人产生高水平的CH4。有趣的是，与正常或加速的人相比，所有产生CH 4的脊髓膜膨出儿童表现出延迟的OCTT和较高的UTI发生率，疏散频率较低。 OCTT。结论：CH 4与便秘之间的联系表明CH 4在便秘的发生中起积极作用。我们研究最有趣的特征之一是确定髓鞘膜膨出，CH 4，延迟OCTT和UTI之间的相关性。在这些儿童中用局部作用药物进行肠道净化可以减少尿路感染的数量并改善肠蠕动。

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