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首页> 外文期刊>Spine >Association of Calcium and Phosphate Balance, Vitamin D, PTH, and Calcitonin in Patients With Adolescent Idiopathic Scoliosis
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Association of Calcium and Phosphate Balance, Vitamin D, PTH, and Calcitonin in Patients With Adolescent Idiopathic Scoliosis

机译：青少年特发性脊柱侧弯患者钙和磷酸盐平衡，维生素D，PTH和降钙素的相关性

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Study Design.A cross-sectional study of 2 groups of patients with scoliosis, and an age-matched control group was conducted. Each of the groups such as patients with adolescent idiopathic scoliosis (AIS) as well as control group were divided additionally into 2 groups: premenarcheal and postmenarcheal girls.Objective.The aim of the study was to determine the levels of 25-OH-vitamin D3, calcium and phosphate, parathyroid hormone (PTH), and calcitonin in serum of pre- and postmenarcheal girls with AIS and corresponding groups of scoliosis-free controls.Summary of Background Data.The primary etiology and pathogenesis of AIS remains unknown. It is assumed that vitamin D deficiency and genetic predisposition, for example, polymorphisms of vitamin D receptor, have a great significance. Vitamin D plays a key role in skeletal development and prevents bone atrophy, affects the absorption of calcium, maintains calcium-phosphate homeostasis, and the bone matrix mineralization. Its deficiency can result in a wide variety of skeletal deformities, low bone mass, and then leads to the disappearance of bone. Defects in trabecular bone structure and/or bone mineralization are the main features of scoliosis. Some studies have reported that Vitamin D deficiency is common among patients with AIS. The mechanism of Vitamin D action on scoliosis development is still unclear.Methods.Determination of serum 25-OH-D3 levels was performed using high-performance liquid chromatography chromatography; concentrations of calcium and phosphate were measured using colorimetric methods, and concentration of PTH and calcitonin was measured using ELISA system.Results.Reduction in the serum levels of 25-OH-D3 and calcitonin in girls with AIS compared with healthy girls was demonstrated.Conclusion.The phosphate-calcium balance and PTH level seem to be normal in patients with AIS. The calcitonin level in girls with AIS is 2-fold lower than in healthy subjects. It is possible that the deficiency of vitamin D can be involved in AIS.Level of Evidence: 4
机译：研究设计：对两组脊柱侧弯患者和年龄匹配的对照组进行横断面研究。青春期特发性脊柱侧凸（AIS）患者和对照组各分为两组，分别为月经前和月经后女孩。目的。研究的目的是确定25-OH-维生素D3的水平。 ，AIS初潮前后女孩血清中的钙，磷酸盐，甲状旁腺激素（PTH）和降钙素及相应的无侧凸对照人群的研究背景资料概述.AIS的主要病因和发病机制仍然未知。假定维生素D缺乏和遗传易感性例如维生素D受体的多态性具有重要意义。维生素D在骨骼发育中起关键作用，并防止骨骼萎缩，影响钙的吸收，维持磷酸钙的稳态和骨骼基质矿化。它的缺乏会导致各种各样的骨骼畸形，低骨量，然后导致骨骼消失。小梁骨结构和/或骨矿化的缺陷是脊柱侧弯的主要特征。一些研究报告说，维生素D缺乏症在AIS患者中很常见。方法尚不清楚。维生素D对脊柱侧弯发展的作用机理尚不清楚。方法：采用高效液相色谱法测定血清25-OH-D3水平;结果：与正常女孩相比，AIS女孩的血清25-OH-D3和降钙素水平降低。结论：与正常女孩相比，AIS女孩血清中25-OH-D3和降钙素水平降低。 AIS患者的磷酸钙平衡和PTH水平似乎正常。患有AIS的女孩的降钙素水平比健康受试者低2倍。维生素D缺乏可能与AIS有关。证据级别：4

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