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首页> 外文期刊>Spine >The presence of pleiotrophin in the human intervertebral disc is associated with increased vascularization: an immunohistologic study.
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The presence of pleiotrophin in the human intervertebral disc is associated with increased vascularization: an immunohistologic study.

机译：人体椎间盘中多效蛋白的存在与血管形成增加有关：一项免疫组织学研究。

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摘要

STUDY DESIGN: An immunohistological study of surgical specimens of human intervertebral disc. OBJECTIVE: To examine the presence of pleiotrophin in diseased or damaged intervertebral disc tissue and the association between its presence and the extent of tissue vascularization and innervation. SUMMARY OF BACKGROUND DATA: Increased levels of pleiotrophin, a growth and differentiation factor that is active in various pathophysiologic processes, including angiogenesis, has been associated with osteoarthritic changes of human articular cartilage. The association between pleiotrophin expression and pathologic conditions of the human intervertebral disc is unknown. METHODS: Specimens of human lumbar intervertebral discs, obtained following surgical discectomy, were divided into 3 groups: non-degenerated discs (n = 7), degenerated discs (n = 6), and prolapsed discs (n = 11). Serial tissue sections of each specimen were immunostained to determine the presence of pleiotrophin, blood vessels (CD34-positive endothelial cells), and nerves (neurofilament 200 kDa [NF200]-positive nerve fibers). RESULTS: Pleiotrophin immunoreactivity was seen in disc cells, endothelial cells, and in the extracellular matrix in most specimens of intervertebral disc but was most prevalent in vascularized tissue in prolapsed discs. There was a significant correlation between the presence of pleiotrophin-positive disc cells and that of CD34-positive blood vessels. NF200-positive nerves were seen in vascularized areas of more degenerated discs, but nerves did not appear to codistribute with blood vessels or pleiotrophin positivity in prolapsed discs. CONCLUSIONS: Pleiotrophin is present in pathologic human intervertebral discs, and its prevalence and distribution suggest that it may play a role in neovascularization of diseased or damaged disc tissue.
机译：研究设计：人体椎间盘手术标本的免疫组织学研究。目的：检查在患病或受损的椎间盘组织中存在多效性蛋白及其存在与组织血管化和神经支配程度之间的关系。背景数据概述：促营养素（一种在各种病理生理过程（包括血管生成）中活跃的生长和分化因子）水平升高与人类关节软骨的骨关节炎改变有关。多种营养蛋白的表达与人类椎间盘病理状况之间的关联是未知的。方法：将经手术椎间盘切除术获得的人腰椎间盘标本分为三组：非变性椎间盘（n = 7），变性椎间盘（n = 6）和脱垂椎间盘（n = 11）。对每个标本的连续组织切片进行免疫染色，以确定存在多效蛋白，血管（CD34阳性内皮细胞）和神经（神经丝200 kDa [NF200]阳性神经纤维）。结果：大多数椎间盘标本在椎间盘细胞，内皮细胞和细胞外基质中均见到了促卵磷脂的免疫反应，但在脱垂椎间盘的血管化组织中最为普遍。多重营养素阳性椎间盘细胞的存在与CD34阳性血管的存在显着相关。在较退化的椎间盘的血管化区域中可见NF200阳性神经，但在脱垂的椎间盘中，神经似乎未与血管共分布或多效性蛋白阳性。结论：磷脂酰胆碱存在于病理性人椎间盘中，其流行和分布表明它可能在患病或受损的椎间盘组织的新生血管形成中起作用。

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