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A synthetic porous ceramic as a bone graft substitute in the surgical management of scoliosis: a prospective, randomized study.

机译:合成多孔陶瓷作为脊柱侧弯手术治疗中的骨移植替代物:一项前瞻性随机研究。

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STUDY DESIGN: A prospective randomized study. OBJECTIVES: To assess the clinical and radiologic performances of a synthetic ceramic as a bone graft substitute in scoliosis surgery. SUMMARY OF BACKGROUND DATA: Surgery on the skeleton frequently requires harvesting of autogenous bone grafts from the pelvis, but this procedure often is complicated by problems. METHODS: Fifty-eight patients with idiopathic scoliosis, ages 13 to 25 years, were treated by posterior correction and arthrodesis using Cotrel-Dubousset instrumentation. Posterior spinal fusion was performed using local bone grafts combined with autogenous iliac bone grafts in 30 patients, and combined with porous biphasic calcium phosphate ceramic blocks comprising hydroxyapatite and tricalcium phosphate in another 28 patients. The patients were observed for a minimum of 24 months after surgery, with a mean postoperative observation time of 48 months. The results were assessed clinically and radiographically. RESULTS: Patients in the ceramic group had a lower average blood loss than those in the iliac graft group. They also were free from postoperative local complications in the iliac region, which were experienced by a significantly high proportion of patients belonging to the iliac graft group. Radiography demonstrated successful incorporation of the ceramic blocks within 12 months. The correction of the deformity was maintained similarly and satisfactorily in both groups. CONCLUSIONS: These results justify and favor the use of calcium phosphate ceramics as bone graft substitutes for instrumented posterior spinal fusion in teenagers and young adults. Potentially hazardous harvesting of pelvic bone is no longer necessary for such operations.
机译:研究设计:一项前瞻性随机研究。目的:评估合成陶瓷在脊柱侧弯手术中作为骨移植替代品的临床和放射学性能。背景数据概述:骨骼外科手术通常需要从骨盆中收集自体骨移植物,但是此过程通常会因问题而变得复杂。方法:对58名13至25岁的特发性脊柱侧弯患者进行了后路矫正和关节固定术(采用Cotrel-Dubousset仪器)。使用局部骨移植物结合自体骨移植物进行后路脊柱融合术的患者为30例,另外使用多孔双相磷酸钙钙陶瓷块(包括羟基磷灰石和磷酸三钙)的患者为28例。术后至少观察24个月,平均术后观察时间48个月。临床和影像学评估结果。结果:陶瓷组患者的平均失血量低于the骨移植组。他们也没有from骨区域的术后局部并发症,属于high骨移植组的患者中有相当高的比例经历了这种并发症。射线照相术显示在12个月内成功地合并了陶瓷块。两组的畸形矫正均相似且令人满意。结论:这些结果证明和赞成使用磷酸钙陶瓷作为骨移植替代物,用于青少年和年轻人的器械化后路脊柱融合术。此类手术不再需要潜在的危险性盆骨收获。

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