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首页> 外文期刊>Modern rheumatology >Cyclosporin A treatment for Japanese patients with severe adult-onset Still's disease.
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Cyclosporin A treatment for Japanese patients with severe adult-onset Still's disease.

机译：环孢菌素A适用于患有严重成人成年斯蒂尔氏病的日本患者。

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For over 10 years there have been no clinical studies about adult-onset Still's disease (AOSD) in Japan. We aimed to investigate recent clinical features and treatment of AOSD and to evaluate the efficacy of cyclosporin A (CyA) in the treatment of AOSD. The data from 34 patients with AOSD who were admitted to our hospital between 1994 and 2007 were analyzed retrospectively. Of several immunosuppressive agents, the efficacy of CyA given to seven patients was precisely evaluated. Clinical features observed in this study did not differ from those in our previous study, and serum ferritin levels were elevated in all the patients. Among immunosuppressive agents CyA, used concomitantly with corticosteroids (CS) for seven patients with severe AOSD, proved to be very effective. The disease was led to remission promptly by CyA in six patients, and all the patients except one experienced no recurrence. These results suggest that CyA can be one of the potent candidates to be used next to CS for patients with AOSDthat is resistant to CS.
机译：在过去的十年中，日本没有关于成人发作性斯蒂尔氏病（AOSD）的临床研究。我们旨在调查AOSD的最新临床特征和治疗，并评估环孢菌素A（CyA）在AOSD治疗中的功效。回顾性分析了1994年至2007年间我院收治的34例AOSD患者的数据。在几种免疫抑制剂中，精确评估了7位患者给予CyA的疗效。这项研究中观察到的临床特征与我们先前的研究没有差异，所有患者的血清铁蛋白水平均升高。在免疫抑制剂CyA中，与皮质类固醇（CS）一起用于7例严重AOSD的患者，被证明是非常有效的。 CyA导致该病迅速缓解，有6例患者，除1例以外其他所有患者均未复发。这些结果表明，对于抗CS的AOSD患者，CyA可能是替代CS的有效候选药物之一。

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