Benefit and a possible risk of tocilizumab therapy for adult-onset Still's disease accompanied by macrophage-activation syndrome.

Kobayashi M; Takahashi Y; Yamashita H; Kaneko H; Mimori A

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Benefit and a possible risk of tocilizumab therapy for adult-onset Still's disease accompanied by macrophage-activation syndrome.

机译：成年人巨噬细胞活化综合征伴发的成年斯蒂尔氏病的托珠单抗治疗的益处和可能的风险。

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We report a 57-year-old female case of intractable adult-onset Still's disease (AOSD). Initial high-dose prednisolone therapy was ineffective, and macrophage-activation syndrome (MAS) manifested after one session of additional tocilizumab therapy. After successful treatment for MAS with lipo-dexamethasone and cyclosporin, tocilizumab therapy aided in the rapid reduction of the therapeutic steroid dose. Tocilizumab may be useful for maintenance therapy for AOSD, although its efficacy is unclear for the highly active phase of the disease.

机译：我们报告一位57岁女性顽固性成人发作的斯蒂尔氏病（AOSD）。最初的大剂量泼尼松龙治疗无效，巨噬细胞活化综合症（MAS）在另一次tocilizumab治疗后出现。用脂地塞米松和环孢菌素成功治疗MAS后，托珠单抗治疗有助于快速降低类固醇的治疗剂量。托珠单抗可能对AOSD的维持治疗有用，尽管尚不清楚该药对疾病的高活性期的疗效。

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《Modern rheumatology》 |2011年第1期|共5页
作者
Kobayashi M; Takahashi Y; Yamashita H; Kaneko H; Mimori A;
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正文语种 eng
中图分类免疫性疾病;
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1. Benefit and a possible risk of tocilizumab therapy for adult-onset Still's disease accompanied by macrophage-activation syndrome. [J] . Kobayashi M, Takahashi Y, Yamashita H, Modern rheumatology . 2011,第1期

机译：成年人巨噬细胞活化综合征伴发的成年斯蒂尔氏病的托珠单抗治疗的益处和可能的风险。
2. Benefit of Tocilizumab Therapy for Adult-Onset Still Disease Complicated With Acute Respiratory Distress Syndrome [J] . Diez Morrondo Carolina, Pantoja Zarza Lucia, Grana Gil Jenaro, Journal of clinical rheumatology . 2016,第5期

机译：Tocilizumab治疗对成人发作的静止性疾病并发急性呼吸窘迫综合征的益处
3. Acquired Amegakaryocytic Thrombocytopenia in Adult-onset Still's Disease: Successful Combination Therapy with Tocilizumab and Cyclosporine [J] . Takanori Ichikawa, Yasuhiro Shimojima, Toshiaki Otuki, Internal medicine. . 2019,第23期

机译：在成人发作的贫困病中获得了亚基约核细胞血小板症：与康斯押沙利和环孢菌素的成功联合治疗
4. Radiobiological Mechanisms and Radiation Risks in Radiotherapy of Benign Diseases [C] . K. R. Trott International congress of radiation research . 2000

机译：良性疾病放射治疗的放射性机制和辐射风险
5. Benefits and risks of gantry-mounted cone beam computed tomography (CBCT) in image guided radiotherapy [D] . Barry, Martin James 2010

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6. Acquired Amegakaryocytic Thrombocytopenia in Adult-onset Stills Disease: Successful Combination Therapy with Tocilizumab and Cyclosporine [O] . Takanori Ichikawa, Yasuhiro Shimojima, Toshiaki Otuki, 2019

机译：在成年的静止病中获得性巨核细胞血小板减少症：Tocilizumab和Cyclosporine的成功联合治疗
7. Acquired Amegakaryocytic Thrombocytopenia in Adult-onset Still's Disease: Successful Combination Therapy with Tocilizumab and Cyclosporine [O] . Takanori Ichikawa, Yasuhiro Shimojima, Toshiaki Otuki, 2019

机译：在成人发作的贫困病中获得了亚基约核细胞血小板症：与康斯押沙利和环孢菌素的成功联合治疗

Benefit and a possible risk of tocilizumab therapy for adult-onset Still's disease accompanied by macrophage-activation syndrome.

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