Peroxisome proliferator-activated receptor gamma in osteoarthritis.

Fahmi H; Martel Pelletier J; Pelletier JP; Kapoor M

首页> 外文期刊>Modern rheumatology >Peroxisome proliferator-activated receptor gamma in osteoarthritis.

【24h】

Peroxisome proliferator-activated receptor gamma in osteoarthritis.

机译：骨关节炎中过氧化物酶体增殖物激活的受体γ。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Osteoarthritis (OA) is among the most prevalent chronic human health disorders and the most common form of arthritis. It is a leading cause of disability in developed countries. This disease is characterized by cartilage deterioration, synovitis, and remodeling of the subchondral bone. There is not yet a satisfactory treatment to stop or arrest this disease process. Although several candidates for therapeutic approaches have been put forward, recent studies suggest that activation of the transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) is an interesting target for this disease. PPARgamma is a ligand-activated transcription factor and member of the nuclear receptor superfamily. Agonists of PPARgamma inhibit inflammation and reduce synthesis of cartilage degradation products both in vitro and in vivo, and reduce the development/progression of cartilage lesions in OA animal models. This review will highlight the recent experimental studies on the presence of PPARgamma in articular tissues and its effect on inflammatory and catabolic responses in chondrocytes and synovial fibroblasts, as well as the protective effects of PPARgamma ligands in arthritis experimental models. Finally, the role of PPARgamma polymorphism in the pathogenesis of OA and related musculoskeletal diseases will also be discussed.

机译：骨关节炎（OA）是最普遍的慢性人类健康疾病之一，也是最常见的关节炎形式。它是发达国家致残的主要原因。这种疾病的特征是软骨恶化，滑膜炎和软骨下骨重塑。尚没有令人满意的疗法来停止或阻止这种疾病的进程。尽管已经提出了几种治疗方法的候选方案，但是最近的研究表明，转录因子过氧化物酶体增殖物激活受体γ（PPARgamma）的激活是该疾病的重要靶标。 PPARγ是配体激活的转录因子，是核受体超家族的成员。在OA动物模型中，PPARγ激动剂在体外和体内均抑制炎症并减少软骨降解产物的合成，并减少软骨损伤的发展/进程。这篇综述将重点介绍关节组织中PPARgamma的存在及其对软骨细胞和滑膜成纤维细胞中炎症和分解代谢反应的影响以及关节炎实验模型中PPARgamma配体的保护作用的最新实验研究。最后，还将讨论PPARgamma多态性在OA和相关的骨骼肌疾病的发病机理中的作用。

著录项

来源
《Modern rheumatology》 |2011年第1期|共9页
作者
Fahmi H; Martel Pelletier J; Pelletier JP; Kapoor M;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词

相似文献

外文文献
中文文献
专利

1. Common polymorphisms of the peroxisome proliferator-activated receptor-gamma (Pro12Ala) and peroxisome proliferator-activated receptor-gamma coactivator-1 (Gly482Ser) and the response to pioglitazone in Chinese patients with type 2 diabetes mellitus. [J] . Hsieh MC, Lin KD, Tien KJ, Metabolism: Clinical and Experimental . 2010,第8期

机译：中国2型糖尿病患者过氧化物酶体增殖物激活受体-γ（Pro12Ala）和过氧化物酶体增殖物激活受体-γcoactivator-1（Gly482Ser）的常见多态性和对吡格列酮的反应。
2. Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1α, (PGC-1α), peroxisome proliferator-activated receptor α (PPARα) and estrogen r [J] . Riad El Kebbaj, Pierre Andreoletti, Hammam I. El Hajj, Biochimie Open . 2015,第3期

机译：摩洛哥坚果油可防止内毒素引起的肝脏脂肪酸氧化和糖异生以及过氧化物酶体增殖物激活受体γcoactivator-1α（PGC-1α），过氧化物酶体增殖物激活受体α（PPARα）和雌激素的下调
3. Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes [J] . VillegasR., WilliamsS.M., GaoY.-T., Annals of Human Genetics . 2014,第1期

机译：过氧化物酶体增殖物激活受体（PPAR）和过氧化物酶体增殖物激活受体γ共激活因子1（PGC1）基因家族和2型糖尿病的遗传变异。
4. Molecular Docking Studies of Flavonoids of Noni Fruit (Morinda citrifolia L.) to Peroxisome Proliferator-Activated Receptor-Gamma (PPAR_γ) [C] . Fikry Awaluddin, Andrianopsyah Mas Jaya Putra, Supandi International Conference on Computation for Science and Technology . 2015

机译：非果（Morinda Citrifolia L.）黄酮类化合物对过氧化物增殖物激活受体 - γ（PPAR_γ）的分子对接研究
5. Peroxisome proliferator-activated receptor gamma (PPARgamma)-independent antitumor effect of thiazolidinediones. [D] . Wei, Shuo. 2010

机译：噻唑烷二酮类药物的过氧化物酶体增殖物激活受体γ（PPARgamma）独立的抗肿瘤作用。
6. Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) peroxisome proliferator-activated receptor α (PPARα) and estrogen related receptor α (ERRα) [O] . Riad El Kebbaj, Pierre Andreoletti, Hammam I. El Hajj, 2015

机译：摩洛哥坚果油可防止内毒素引起的肝脏脂肪酸氧化和糖异生以及过氧化物酶体增殖物激活受体γcoactivator-1α（PGC-1α）过氧化物酶体增殖物激活受体α（PPARα）和雌激素相关受体α（ERRα）的下调。）
7. Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1 alpha, (PGC-1alpha), peroxisome proliferator-activated receptor gamma (PPARgamma) and estrogen related receptor alpha (ERRalpha) [O] . Kebbaj, Riad,, ANDREOLETTI, Pierre, El Hajj, Hammam,, 2015

机译：摩洛哥坚果油可防止内毒素引起的肝脏脂肪酸氧化和糖异生以及过氧化物酶体增殖物激活受体γcoactivator-1 alpha（PGC-1alpha），过氧化物酶体增殖物激活受体γ（PPARgamma）和雌激素相关受体α（ ERRalpha）

Peroxisome proliferator-activated receptor gamma in osteoarthritis.

摘要

著录项

相似文献

相关主题

期刊订阅