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首页> 外文期刊>Modern rheumatology >Disease activity and the course of wrist joint deterioration over 10 years in the patients with early rheumatoid arthritis.
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Disease activity and the course of wrist joint deterioration over 10 years in the patients with early rheumatoid arthritis.

机译：早期类风湿关节炎患者的疾病活动性和腕关节恶化过程超过10年。

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The objectives of this study were to evaluate the course of radiographic deterioration of the wrist joint with rheumatoid arthritis (RA), and to determine the influence of disease activity on its deterioration. A retrospective study was performed on 122 wrists in 66 patients, who started treatment using disease-modifying antirheumatic drugs within the first year of the disease and followed for more than 10 years without surgical intervention. The mean disease activity score (DAS28-CRP[3]) was high during the first 2 years, followed by a decrease and a flattening of the curve of disease activity. Generally, carpal collapse progressed more in the early stage and decreased linearly over 10 years. Individually, continuous high disease activity and progression in radiographic damage were observed in carpal collapsed groups from early stage of the disease. The cut-off values of the mean DAS28-CRP(3) during year 0-2, which indicated progression to Larsen grade III or more and Schulthess type I (ankylosis) or III (disintegration) at year 10 were 3.34 (sensitivity: 70.9% and specificity: 72.1%) and 3.63 (sensitivity: 74.3% and specificity: 77.0%), respectively. In patients with RA, deterioration of the wrist joint was influenced by disease activity. Identifying this activity and the course of wrist progression may be useful in predicting wrist deterioration.
机译：这项研究的目的是评估类风湿性关节炎（RA）腕关节的影像学恶化过程，并确定疾病活动对其恶化的影响。一项回顾性研究在66名患者中进行，研究对象为122名手腕，这些患者在疾病发生的第一年内开始使用改变疾病的抗风湿药进行治疗，随后进行了10多年的手术治疗。在最初的2年中，平均疾病活动评分（DAS28-CRP [3]）高，其后疾病活动曲线降低并趋于平坦。通常，腕骨塌陷在早期阶段进展更多，并在10年内呈线性下降。从疾病的早期阶段开始，在腕关节塌陷组中观察到了持续的高疾病活动性和放射线照相损伤的进展。 0-2年期间的平均DAS28-CRP（3）的临界值表明在10年时已发展为Larsen III级或更高，Schulthess I型（强直性）或III型（崩解），其临界值为3.34（敏感性：70.9） ％和特异性：72.1％）和3.63（敏感性：74.3％和特异性：77.0％）。在RA患者中，腕关节的恶化受到疾病活动的影响。识别这种活动和手腕的前进过程可能有助于预测手腕的恶化。

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