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首页> 外文期刊>Biomaterials >Long-term stability of bone tissues induced by an osteoinductive biomaterial, recombinant human bone morphogenetic protein-2 and a biodegradable carrier
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Long-term stability of bone tissues induced by an osteoinductive biomaterial, recombinant human bone morphogenetic protein-2 and a biodegradable carrier

机译：骨诱导性生物材料，重组人骨形态发生蛋白2和可生物降解的载体诱导的骨组织的长期稳定性

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The long-term stability of bone tissues induced by recombinant human bone morphogenetic protein-2 (rhBMP-2) and poly[L-lactide-co-glycolide] copolymer-coated gelatin sponge (PGS) was examined. In 16 dogs, 2.5 cm unilateral bone defects were created in the left tibial diaphyses. Tibia was fixed with metal plate, and PGS impregnated with (0.4 mg/cm(3)) or without rhBMP-2 was implanted into 15 or one defects, respectively. The metal plates of rhBMP-2-treated limbs were removed 16 weeks after the implantation. The bilateral tibiae of five animals each of the rhBMP-2-treated group were harvested at 32, 52 or 104 weeks, and served for biomechanical testing and histology. Although the defect that received PGS alone resulted in nonunion at 16 weeks, all defects treated with rhBMP-2 achieved radiographic bony union by 8 weeks. Biomechanical properties of the regenerated bones restored to the levels of intact tibiae at 32 weeks, but torsional stiffness was significantly higher. No statistical significances were detected in all parameters between regenerated and intact tibiae at 104 weeks. No radiographic and histological findings suggesting enhanced resorption to the regenerated bones were observed. These results suggest the long-term stability of the bone tissues induced by rhBMP-2, and the usefulness of rhBMP-2-impregnated PGS as a biomaterial for long bone defect filling. (C) 2003 Elsevier Ltd. All rights reserved. [References: 28]
机译：研究了重组人骨形态发生蛋白2（rhBMP-2）和聚[L-丙交酯-乙交酯共聚物]包被的明胶海绵（PGS）诱导的骨组织的长期稳定性。在16只狗中，左胫骨干骨形成2.5厘米的单侧骨缺损。用金属板固定胫骨，将含（0.4 mg / cm（3））或无rhBMP-2的PGS分别植入15个或一个缺损中。植入16周后，去除了rhBMP-2处理过的肢体的金属板。在rhBMP-2处理组中，分别在32、52或104周时收获了五只动物的双侧胫骨，用于生物力学测试和组织学检查。尽管仅接受PGS的缺损在16周时导致骨不连，但所有用rhBMP-2治疗的缺损均在8周时达到了放射照相的骨结合。再生骨骼的生物力学特性在32周时恢复到完整的胫骨水平，但扭转刚度明显更高。在104周时，在再生胫骨和完整胫骨之间的所有参数中均未检测到统计学意义。没有影像学和组织学发现提示对再生骨骼的吸收增强。这些结果表明由rhBMP-2诱导的骨组织的长期稳定性，以及用rhBMP-2浸渍的PGS作为长骨缺损填充的生物材料的实用性。 （C）2003 Elsevier Ltd.保留所有权利。 [参考：28]

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