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首页> 外文期刊>Stem cell research >The Characterization Tool: A knowledge-based stem cell, differentiated cell, and tissue database with a web-based analysis front-end
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The Characterization Tool: A knowledge-based stem cell, differentiated cell, and tissue database with a web-based analysis front-end

机译：表征工具：基于知识的干细胞，分化细胞和组织数据库，具有基于Web的分析前端

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摘要

In the rapidly growing field of stem cell research, there is a need for universal databases and web-based applications that provide a common knowledge base on the characteristics of stem cells, differentiated cells, and tissues by collecting, processing, and making available diverse types of characterization data. The Characterization Toot is such a novel knowledge database that allows the storage of various characteristics of cells, cell tines, and tissues across different species as well as the analysis of associated marker profiles. Its broad ontology-based framework facilitates the integration of characterization data on the morphological, molecular, and functional level. acquired in vivo and in vitro including published marker expressions, cross-references to other databases, text descriptions, information on characterization experiments, and image storage. Data input and modification are recorded on the basis of a secure user management. By means of several easy-to-use data mining tools, marker profiles can be searched and analyzed. The Characterization Toot will aid in the establishment of standards for cell characterization, needed, for example, for stem cell isolation, propagation, and differentiation. The Characterization Toot is available at http://characterizationtool.cellnet.org. It currently holds more than 7000 marker expressions for different human embryonic stem cell lines, adult stem cells, and differentiated cells.
机译：在快速发展的干细胞研究领域中，需要通用数据库和基于Web的应用程序，这些数据库和网络应用程序通过收集，处理和提供多种类型来提供有关干细胞，分化细胞和组织特征的公共知识。表征数据。表征嘟嘟是一种新颖的知识数据库，它可以存储跨不同物种的细胞，尖齿和组织的各种特征，并分析相关的标记物。其广泛的基于本体的框架有助于在形态，分子和功能水平上整合表征数据。可在体内和体外获得，包括公开的标志物表达，对其他数据库的交叉引用，文本描述，有关表征实验的信息以及图像存储。数据输入和修改都基于安全的用户管理进行记录。通过几种易于使用的数据挖掘工具，可以搜索和分析标记配置文件。表征嘟嘟将有助于建立细胞表征标准，例如干细胞分离，繁殖和分化所需要的标准。可从http://characterizationtool.cellnet.org获得“表征嘟嘟”。目前，它针对不同的人类胚胎干细胞系，成年干细胞和分化细胞拥有7000多种标志物表达。

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