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首页> 外文期刊>Stereotactic and Functional Neurosurgery: Official Journal of the World Society for Stereotactic and Functional Neurosurgery >Tolerance and tremor rebound following long-term chronic thalamic stimulation for Parkinsonian and essential tremor.
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Tolerance and tremor rebound following long-term chronic thalamic stimulation for Parkinsonian and essential tremor.

机译：长期长期丘脑刺激帕金森氏病和原发性震颤后，耐受性和震颤反弹。

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摘要

Fifty-eight patients, 36 with essential tremor (ET) and 22 with Parkinson's disease (PD), received deep brain stimulation (DBS) in the thalamic ventral intermediate (Vim) nucleus. The mean follow-up was 17 months for ET and 21 months for PD patients. Stimulation parameters were adjusted as needed, at various intervals after surgery. Results were assessed using routine clinical evaluation and established outcome scales. All patients needed incremental increase in stimulation parameters at various intervals during the first 6-12 months after surgery. The mean voltage 1 week postoperatively was 1. 45 V in PD patients, and 1.37 V in ET patients. Twelve months later, the figures were 2.14 V in PD and 2.25 V in ET patients. At 1 year, the Essential Tremor Rating Scale (ETRS) improved from 54 to 28 (p < 0.0001). The motor part of the Unified Parkinson's Disease Rating Scale (UPDRS) improved from 37 to 26 (p < 0.01). Tremor items of the UPDRS improved more markedly (p < 0.0001). One week postoperatively 90% of PD, and 89% of ET patients were tremor free. One year later, 70% of PD and 60% of ET patients remained mostly tremor free. Upon switching off stimulation, there was a clear tendency for tremor rebound (p = 0.07) in the PD group, requiring continuous 24-hour stimulation in some patients. Permanent non-adjustable ataxia was induced by stimulation in 2 PD patients. Copyright 2000 S. Karger AG, Basel
机译：58名患者，其中36名患有原发性震颤（ET），而22名患有帕金森氏病（PD），在丘脑腹侧中间（Vim）核接受了深部脑刺激（DBS）。 ET的平均随访时间为17个月，PD患者的平均随访时间为21个月。在手术后的不同间隔内，根据需要调整刺激参数。使用常规临床评估和建立的结果量表评估结果。在手术后的最初6至12个月内，所有患者均需要在不同的时间间隔增加刺激参数。术后1周的平均电压在PD患者中为1. 45 V，在ET患者中为1.37V。十二个月后，PD患者为2.14 V，ET患者为2.25V。在1年时，基本震颤评定量表（ETRS）从54提高到28（p <0.0001）。帕金森病综合评分量表（UPDRS）的运动部分从37提高到26（p <0.01）。 UPDRS的震颤项改善更为显着（p <0.0001）。术后1周PD的90％和ET患者的89％无震颤。一年后，仍然有70％的PD和60％的ET患者保持无震颤。停止刺激后，PD组有明显的震颤反弹趋势（p = 0.07），某些患者需要连续24小时刺激。 2例PD患者经刺激引起永久性非可调性共济失调。版权所有2000 S. Karger AG，巴塞尔

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