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Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis.

机译：肿瘤坏死因子基因多态性和偏头痛：系统评价和荟萃分析。

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BACKGROUND: Data on the association between TNFalpha and TNFbeta gene polymorphisms and migraine are conflicting. METHODS: We performed a systematic review and meta-analysis of studies published until January 2011. We used data from published papers and as provided after contact with the authors. We calculated study specific odds ratios (OR) and 95% confidence intervals (CI) assuming additive, dominant, and recessive genetic models as well as pooled effect estimates. RESULTS: Among the ten studies identified, the best evidence is available for the TNFalpha -308G>A and TNFbeta 252A > G polymorphisms indicating no overall association with migraine. Subgroup analyses suggested that the A allele of the TNFalpha -308G > A variant more than doubles the risk for migraine among populations with a heterogeneous ethnic background, which was driven by associations for migraine without aura (additive model: pooled OR = 2.87, 95% CI 1.86-4.43). Further, the risk for migraine with aura was increased among Asian populations (additive model: pooled OR = 1.71, 95% CI 1.07-2.71). Both observed effects were stronger among females than males. CONCLUSIONS: Our results indicate no overall association between TNFalpha and TNFbeta gene variants and migraine. However, associations differed among specific populations. Our findings need to be treated with caution and further targeted research is warranted to evaluate population-specific effects including population stratification.
机译：背景：关于TNFalpha和TNFbeta基因多态性与偏头痛之间关联的数据存在矛盾。方法：我们对发表至2011年1月的研究进行了系统的回顾和荟萃分析。我们使用了已发表论文的数据，并与作者联系后提供了数据。我们计算了研究的特定优势比（OR）和95％置信区间（CI），并假设了累加，显性和隐性遗传模型以及汇总效应估计。结果：在确定的十项研究中，关于TNFalpha -308G> A和TNFbeta 252A> G多态性的最佳证据是可用的，表明与偏头痛没有整体联系。亚组分析表明，TNFalpha -308G> A变异的A等位基因使种族背景不同的人群发生偏头痛的风险增加了一倍以上，这是由无先兆偏头痛的关联引起的（累加模型：合并OR = 2.87，95％ CI 1.86-4.43）。此外，亚洲人群中有先兆偏头痛的风险增加（累加模型：合并OR = 1.71，95％CI 1.07-2.71）。两种观察到的影响在女性中都比男性强。结论：我们的结果表明TNFalpha和TNFbeta基因变异与偏头痛之间没有整体联系。但是，特定人群之间的关联有所不同。我们的发现需要谨慎对待，有必要进行进一步的针对性研究来评估特定人群的影响，包括人群分层。

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