Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache

Burgos-Vega Carolina C.; Ahn David Dong-Uk; Bischoff Christina; Wang Weiya; Horne Dan; Wang Judy; Gavva Narender; Dussor Gregory

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Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache

机译：临床前啮齿动物头痛模型中的脑膜短暂受体潜在通道M8激活导致皮肤面部和后爪异常性疼痛

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Background Migraine headache is a neurological disorder affecting millions worldwide. However, little is known about the mechanisms contributing to migraine. Recent genome-wide association studies have found single nucleotide polymorphisms in the gene encoding transient receptor potential channel M8. Transient receptor potential channel M8 is generally known as a cold receptor but it has been implicated in pain signaling and may play a role in migraine pain.

机译：背景偏头痛是一种影响全世界数百万人的神经系统疾病。但是，关于偏头痛的机制知之甚少。最近的全基因组关联研究发现，在编码瞬时受体电位通道M8的基因中存在单核苷酸多态性。瞬时受体电位通道M8通常被称为感冒受体，但它与疼痛信号有关，并可能在偏头痛中起作用。

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《Cephalalgia》 |2016年第2期|共9页
作者
Burgos-Vega Carolina C.; Ahn David Dong-Uk; Bischoff Christina; Wang Weiya; Horne Dan; Wang Judy; Gavva Narender; Dussor Gregory;
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正文语种 eng
中图分类诊断学;
关键词
Transient receptor potential channel M8; headache; dura; migraine; allodynia; cold; sumatriptan;

机译：瞬时受体电位通道M8;头痛;硬脑膜;偏头痛;异常性疼痛;感冒;舒马曲坦;

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1. Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache [J] . Burgos-Vega Carolina C., Ahn David Dong-Uk, Bischoff Christina, Cephalalgia . 2016,第2期

机译：临床前啮齿动物头痛模型中的脑膜短暂受体潜在通道M8激活导致皮肤面部和后爪异常性疼痛
2. Role of transient receptor potential ankyrin 1 receptors in rodent models of meningeal nociception - Experiments invitro [J] . Denner A. C., Vogler B., Messlinger K., European journal of pain : . 2017,第5期

机译：瞬时受体潜在肛门虫1受体在脑膜脑膜鼻肌鼻咽模型中的作用 - 实验invitro
3. Reduced cardiac ischemia/reperfusion injury by hypothermic reperfusion via activation of transient receptor potential M8 channel [J] . Cheng Quan-yi, Yang Meng-cheng, Wu Jing, Life sciences . 2019,第期

机译：通过激活瞬态受体潜在M8通道，减少心脏缺血/再灌注损伤。
4. Validation of the Transient Receptor Potential Vanilloid 6 Channel (TRPV6) as a Potential Biomarker in Ovarian Cancers [C] . Dominique Dugourd, Tyler Lutes, Christopher Rice, PEGS . 2015

机译：在卵巢癌中验证瞬态受体潜在的激素6声道（TRPV6）作为潜在的生物标志物
5. Role of Transient Receptor Potential Vanilloid 1 and Oxidation in a Rodent Model of Nerve Growth Factor-Induced Persistent Pain [D] . Eskander, Michael Andrew. 2019

机译：暂时性受体电位香草醛1和氧化在啮齿动物神经生长因子诱导的持续性疼痛模型中的作用。
6. Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache [O] . Carolina C Burgos-Vega, David Dong-Uk Ahn, Christina Bischoff, -1

机译：临床前啮齿动物头痛模型中的脑膜短暂受体潜在通道M8激活导致皮肤面部和后爪异常性疼痛
7. Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache [O] . Carolina C Burgos-Vega, David Dong-Uk Ahn, Christina Bischoff, 2015

机译：脑膜瞬时受体潜在通道M8活化导致皮肤面部和后爪异常在头痛的临床前啮齿动物模型中

Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache

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