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Cortical spreading depression in migraine.

机译：偏头痛的皮质扩散抑制。

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摘要

Cortical spreading depression (CSD) is associated with a dramatic failure of brain ion homeostasis as well as efflux of excitatory amino acids from nerve cells and increased energy metabolism. There is strong clinical and experimental evidence to suggest that CSD is involved in the mechanism of migraine. This paper will, based on the experience related to the detection of CSD in humans, discuss pitfalls and possible strategies for detection of CSD in man. Development of reliable methods for detection of CSD in humans will determine the extent to which the large body of experimental findings from animal studies of CSD can be applied to the investigation and treatment of human brain disease. The paper is based on the experience that has been gained from two decades of studies of CSD in relation to clinical neurological diseases.
机译：皮质扩散抑制（CSD）与脑离子动态平衡的急剧衰竭以及神经细胞的兴奋性氨基酸外排和能量代谢增加有关。有强大的临床和实验证据表明CSD参与了偏头痛的机制。本文将基于与人类CSD检测相关的经验，讨论人类CSD检测的陷阱和可能的策略。可靠的人类CSD检测方法的开发将决定从CSD动物研究获得的大量实验结果可用于人类脑部疾病的研究和治疗的程度。本文基于从对临床神经病学的CSD研究的二十年中获得的经验。

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