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首页> 外文期刊>Steroids: An International Journal >TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo
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TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo

机译：TXA9是来自Jueptas链霉菌的强心苷，可在体内和体外对人非小细胞肺癌细胞发挥有效的抗肿瘤活性

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Non-small cell lung cancer is the most common type of lung cancer and the most common cause of cancer-related death in humans. TXA9, which is a natural product separated from an anti-tumor-active fraction of the roots of Streptocaulon juventas, may possess potent anti-proliferative activity according to the present study. In this study, the anti-tumor effects and toxicity of TXA9 were tested against human non-small cell lung cancer cell lines (A549, NCI-H1299, Ltep-alpha 2, PC-9, and Lu99) and a normal human lung embryonic fibroblast cell (HE-lung) in vitro, and then toward A549 cells in vivo in a murine xenograft model. The results show that TXA9 exhibits potent cytotoxic activities against non-small lung cancer cells and has no toxic effect on the normal human lung embryonic fibroblast cells. The mechanistic studies demonstrate that TXA9 can induce the apoptosis of A549 cells through the extrinsic pathway. The in vivo study results reveal that the intravenous administration of TXA9 at high-dose (15 mg kg) induces significant tumor growth inhibition of non-small cell lung cancer xenografts with tumor inhibition rate up to 64.2%, compared with mice in the control group. The inhibitory effect was similar to that of taxol (62.5%). In particular, no significantly adverse effects were exerted by TXA9, which suggests that it is well tolerated. This promising natural product may be useful as a potential novel anti-tumor candidate. (C) 2014 Elsevier Inc. All rights reserved.
机译：非小细胞肺癌是最常见的肺癌类型，也是人类与癌症相关的死亡的最常见原因。根据本研究，TXA9是一种天然产物，与Juventas链霉菌根的抗肿瘤活性部分分离，它可能具有有效的抗增殖活性。在这项研究中，测试了TXA9对人非小细胞肺癌细胞系（A549，NCI-H1299，Ltep-alpha 2，PC-9和Lu99）和正常人肺胚胎的抗肿瘤作用和毒性。在鼠异种移植模型中，先体外培养成纤维细胞（HE-肺），然后体内研究A549细胞。结果表明，TXA9对非小肺癌细胞具有有效的细胞毒性作用，对正常人的肺胚成纤维细胞没有毒性作用。机理研究表明，TXA9可以通过外源途径诱导A549细胞凋亡。体内研究结果表明，与对照组小鼠相比，大剂量（15 mg / kg）静脉内注射TXA9可以显着抑制非小细胞肺癌异种移植物的肿瘤生长，肿瘤抑制率高达64.2％。 。抑制作用与紫杉醇相似（62.5％）。特别是，TXA9并未产生明显的不良反应，这表明它具有良好的耐受性。这种有前途的天然产物可用作潜在的新型抗肿瘤候选物。 （C）2014 Elsevier Inc.保留所有权利。

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