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首页> 外文期刊>Stem cell reviews >Some dynamic aspects of hematopoietic stem cells.
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Some dynamic aspects of hematopoietic stem cells.

机译:造血干细胞的一些动态方面。

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摘要

Hematopoiesis is the process responsible for maintaining the number of circulating blood cells that are undergoing continuous turnover. At the root of this process are the hematopoietic stem cells (HSC). In the following we discuss various dynamic aspects of HSC behavior ranging from the number of active stem cells, their expansion during ontogeny and the importance of stochastic effects on their behavior. We show how mathematical modeling of HSC behavior can provide important insights on these cells and clarify the implications of these dynamical aspects on healthy and sick individuals, as such providing rational explanations for relevant clinical observations on disorders that originate in this group of cells.
机译:造血作用是维持循环中不断循环的血细胞数量的过程。造血干细胞(HSC)是这一过程的根本。在下文中,我们讨论了HSC行为的各个动态方面,包括活跃的干细胞的数量,它们在个体发育过程中的扩增以及随机效应对其行为的重要性。我们展示了HSC行为的数学建模如何能够提供对这些细胞的重要见解,并阐明这些动力学方面对健康和患病个体的影响,从而为对源自该组细胞的疾病的相关临床观察提供了合理的解释。

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