The influence of Cu(II), Mg(II) on the binding of adriamycin with DNA and the study on their interaction mechanism

Yuan XY; Guo DS; Zhang M

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The influence of Cu(II), Mg(II) on the binding of adriamycin with DNA and the study on their interaction mechanism

机译：Cu（II），Mg（II）对阿霉素与DNA结合的影响及其相互作用机理的研究

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Cu(II) and Mg(II) have different binding capacity with daunomycin, and have different combination mode with DNA. Selecting these two different metal ions, the influence of them on the binding constant of adriamycin with DNA and the related mechanism has been studied by using absorption and fluorescence spectroscopy. The result showed that Mg(II) has weaker binding capacity with the drug comparing Cu(II), but both Mg(IT) and Cu(II) can obviously reduce the binding constant of DNA with the drug. Addition of Cu(II) to the drug-DNA binary system can cause the reduction of fluorescence in the system, but addition of Mg(II) to it can cause the enhancement of fluorescence in some conditions. This show that the influence of Cu(II) and Mg(II) on the binding of the drug with DNA may be by a different mechanism. According to the main function of Mg(II) to bind with the phosphate groups on DNA, it can be deduced that for the interaction of the aglycon portion of the drug into the base pairs of DNA, the electrostatic binding between amine group of the drug with the phosphate group on DNA is a prerequisite. (c) 2005 Elsevier B.V. All rights reserved.

机译：Cu（II）和Mg（II）与道诺霉素的结合能力不同，与DNA的结合方式也不同。选择了这两种不同的金属离子，利用吸收光谱和荧光光谱研究了它们对阿霉素与DNA结合常数的影响及其相关机理。结果表明，Mg（II）与药物的结合能力较Cu（II）弱，但Mg（IT）和Cu（II）均可明显降低DNA与药物的结合常数。在药物-DNA二元体系中添加Cu（II）会导致系统中荧光的减少，但是在某些条件下向其中添加Mg（II）会导致荧光的增强。这表明Cu（II）和Mg（II）对药物与DNA结合的影响可能是通过不同的机制。根据Mg（II）与DNA磷酸基团结合的主要功能，可以推论出对于药物的糖苷配基部分与DNA碱基对的相互作用，药物的胺基之间的静电结合先决条件是在DNA上带有磷酸基。（c）2005 Elsevier B.V.保留所有权利。

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《Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy》 |2006年第2期|共5页
作者
Yuan XY; Guo DS; Zhang M;
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正文语种 eng
中图分类分析化学;
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adriamycin; calf thymus DNA; Cu(II) and Mg(II); fluorescence; ultraviolet absorption; DEOXYRIBONUCLEIC-ACID COMPLEX; DAUNOMYCIN;

机译：阿霉素;小牛胸腺DNA;Cu（II）和Mg（II）;荧光;紫外吸收;脱氧核糖核酸复合物;桃金霉素;

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1. The influence of Cu(II), Mg(II) on the binding of adriamycin with DNA and the study on their interaction mechanism [J] . Yuan XY, Guo DS, Zhang M Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy . 2006,第2期

机译：Cu（II），Mg（II）对阿霉素与DNA结合的影响及其相互作用机理的研究
2. Synthesis of new piperazine derived Cu(II)/Zn(II) metal complexes, their DNA binding studies, electrochemistry and anti-microbial activity: Validation for specific recognition of Zn(II) complex to DNA helix by interaction with thymine base [J] . Bhat IUH, Tabassum S Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy . 2009,第5期

机译：合成新的哌嗪衍生的Cu（II）/ Zn（II）金属配合物，其DNA结合研究，电化学和抗微生物活性：验证与胸腺嘧啶碱基相互作用对Zn（II）配合物对DNA螺旋的特异性识别
3. Interaction of rac-[Cu(diimine)(3)](2+) and rac-[Zn(diimine)(3)](2+) complexes with CT DNA: effect of fluxional Cu(II) geometry on DNA binding, ligand-promoted exciton coupling and prominent DNA cleavage [J] . Ramakrishnan S, Palaniandavar M Dalton transactions: An international journal of inorganic chemistry . 2008,第29期

机译：rac- [Cu（diimine）（3）]（2+）和rac- [Zn（diimine）（3）]（2+）配合物与CT DNA的相互作用：通量Cu（II）几何形状对DNA结合的影响，配体促进的激子偶联和突出的DNA裂解
4. Towards an understanding of protein-protein interaction network hierarchies. Analysis of DnaN (β)-binding peptide motifs in members of protein families interacting with the eubacterial processivity clamp, the β subunit of DNA Polymerase III [C] . Brian P. Dalrymple, Gene Wijffels, Kritaya Kongsuwan, Asia-Pacific Bioinformatics Conference(APBC 2003); 200302; Adelaide(AU) . 2003

机译：对蛋白质-蛋白质相互作用网络层次结构的理解。蛋白质家族成员与DNA聚合酶III的优生过程性钳位相互作用的DnaN（β）结合肽基序分析
5. Zinc finger interactions with nucleic acids: I. Mechanism of monomeric DNA binding by the orphan nuclear receptor hERR2. II. TFIIIA and p43 interactions with 5S RNA. [D] . Gearhart, Micah David. 2001

机译：锌指与核酸的相互作用：I.孤核受体hERR2与单体DNA结合的机制。二。 TFIIIA和p43与5S RNA相互作用。
6. A laser Raman spectroscopic study of the interaction of calf-thymus DNA with Cu(II) and Pb(II) ions: metal ion binding and DNA conformational changes. [O] . H A Tajmir-Riahi, M Langlais, R Savoie 1988

机译：小牛胸腺DNA与Cu（II）和Pb（II）离子相互作用的激光拉曼光谱研究：金属离子结合和DNA构象变化。
7. DNA binding, BSA interaction and in-vitro antimicrobial studies of Cu(II), Co(III), Ni(II) and VO(IV) complexes with a new Schiff base [O] . Disha Sharma, Hosakere D. Revanasiddappa, Basavegowda Jayalakshmi 2020

机译：DNA结合，BSA相互作用和Cu（II），CO（III），Ni（II）和VO（IV）复合物与新的Schiff Base的综合性抗微生物研究

The influence of Cu(II), Mg(II) on the binding of adriamycin with DNA and the study on their interaction mechanism

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