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首页> 外文期刊>Spectrochimica Acta, Part B. Atomic Spectroscopy >Discriminant analysis of trace elements in normal, benign and malignant breast tissues measured by total reflection X-ray fluorescence
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Discriminant analysis of trace elements in normal, benign and malignant breast tissues measured by total reflection X-ray fluorescence

机译：用全反射X射线荧光法对正常，良性和恶性乳腺组织中的微量元素进行判别分析

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in this work total reflection X-ray fluorescence spectrometry has been employed to determine trace element concentrations in different human breast tissues (normal, normal adjacent, benign and malignant). A multivariate discriminant analysis of observed levels was performed in order to build a predictive model and perform tissue-type classifications. A total of 83 breast tissue samples were studied. Results showed the presence of Ca, Ti, Fe, Cu and Zn in all analyzed samples. All trace elements, except Ti, were found in higher concentrations in both malignant and benign tissues, when compared to normal tissues and normal adjacent tissues. In addition, the concentration of Fe was higher in malignant tissues than in benign neoplastic tissues. An opposite behavior was observed for Ca, Cu and Zn. Results have shown that discriminant analysis was able to successfully identify differences between trace element distributions from normal and malignant tissues with an overall accuracy of 80% and 65% for independent and paired breast samples respectively, and of 87% for benign and malignant tissues.
机译：在这项工作中，已采用全反射X射线荧光光谱法测定不同人体乳腺组织（正常，正常邻近，良性和恶性）中的痕量元素浓度。为了建立预测模型并进行组织类型分类，对观察到的水平进行了多因素判别分析。共研究了83个乳腺组织样本。结果表明，所有分析样品中均存在钙，钛，铁，铜和锌。与正常组织和正常相邻组织相比，除Ti外，所有痕量元素在恶性和良性组织中的浓度均较高。另外，恶性组织中的Fe浓度高于良性肿瘤组织中的Fe浓度。对于Ca，Cu和Zn观察到相反的行为。结果表明，判别分析能够成功地识别出正常组织和恶性组织中微量元素分布之间的差异，独立和成对的乳腺样品的总准确度分别为80％和65％，良性和恶性组织的总准确度分别为87％。

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