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首页> 外文期刊>Statistics in medicine >A semi-competing risks model for data with interval-censoring and informative observation: an application to the MRC cognitive function and ageing study.
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A semi-competing risks model for data with interval-censoring and informative observation: an application to the MRC cognitive function and ageing study.

机译:具有间隔检查和信息观察的数据的半竞争风险模型:在MRC认知功能和衰老研究中的应用。

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摘要

Semi-competing risks data occur frequently in medical research when interest is in simultaneous modelling of two or more processes, one of which may censor the others. We consider the analysis of semi-competing risks data in the presence of interval-censoring and informative loss-to-followup. The work is motivated by a data set from the MRC UK Cognitive Function and Ageing Study, which we use to model two processes, cognitive impairment and death. Analysis is carried out using a multi-state model, which is an extension of that used by Siannis et al. (Statist. Med. 2007; 26:426-442) to model semi-competing risks data with exact transition times, to data which is interval-censored. Model parameters are estimated using maximum likelihood. The role of a sensitivity parameter k, which influences the nature of informative censoring, is explored.
机译:当人们关注同时建模两个或多个过程时,半竞争风险数据经常出现在医学研究中,其中一个可能会检查其他过程。我们考虑在存在间隔检查和信息丢失的情况下对半竞争风险数据的分析。这项工作是根据英国MRC认知功能和衰老研究的数据集进行的,我们使用该数据集对两个过程(认知障碍和死亡)进行建模。使用多状态模型进行分析,该模型是Siannis等人使用的模型的扩展。 (Statist。Med。2007; 26:426-442),以具有精确过渡时间的半竞争风险数据建模为间隔检查的数据。使用最大似然估计模型参数。探索了敏感度参数k的作用,它影响了信息审查的性质。

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