...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Structure >Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3
【24h】

Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3

机译：FasL及其诱饵受体DcR3的复合物的晶体结构

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The apoptotic effect of FasL:Fas signaling is disrupted by DcR3, a unique secreted member of the tumor necrosis factor receptor superfamily, which also binds and neutralizes TL1A and LIGHT. DcR3 is highly elevated in patients with various tumors and contributes to mechanisms by which tumor cells to evade host immune surveillance. Here we report the crystal structure of FasL in complex with DcR3. Comparison of FasL: DcR3 structure with our earlier TL1A:DcR3 and LIGHT:DcR3 structures supports a paradigm involving the recognition of invariant main-chain and conserved side-chain functionalities, which is responsible for the recognition of multiple TNF ligands exhibited by DcR3. The FasL:DcR3 structure also provides insight into the FasL:Fas recognition surface. We demonstrate that the ability of recombinant FasL to induce Jurkat cell apoptosis is significantly enhanced by native glycosylation or by structure-inspired mutations, both of which result in reduced tendency to aggregate. All of these activities are efficiently inhibited by recombinant DcR3.
机译：FasL：Fas信号转导的凋亡作用被DcR3破坏，DcR3是肿瘤坏死因子受体超家族的独特分泌成员，它也结合并中和TL1A和LIGHT。 DcR3在患有各种肿瘤的患者中高度升高，并有助于肿瘤细胞逃避宿主免疫监视的机制。在这里，我们报告了与DcR3复合的FasL的晶体结构。 FasL：DcR3结构与我们较早的TL1A：DcR3和LIGHT：DcR3结构的比较支持涉及识别恒定主链和保守侧链功能的范式，该范式负责识别DcR3展示的多个TNF配体。 FasL：DcR3结构还可以洞悉FasL：Fas识别表面。我们证明了重组FasL诱导Jurkat细胞凋亡的能力通过天然糖基化或结构启发性突变得到了显着增强，二者均导致聚集的趋势降低。所有这些活性均被重组DcR3有效抑制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号