• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Substance use & misuse >What aspects of human alcohol use disorders can be modeled using selectively bred rat lines?
【24h】

What aspects of human alcohol use disorders can be modeled using selectively bred rat lines?

机译：使用选择性繁殖的大鼠品系可以模拟人类酒精使用障碍的哪些方面？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The use of selective breeding to produce animal models for the study of alcohol abuse and alcoholism represents one of the major advances in the field of alcohol research. Rats selectively bred for alcohol preference and alcohol nonpreference have been useful to both preclinical and clinical investigators in the alcohol research community for studying the behavioral, neurobiological, and molecular basis of alcohol drinking, for identifying the genes that may contribute to the development of alcohol abuse and alcoholism, and for evaluating the utility of drugs aimed at reducing alcohol intake and preventing alcohol relapse. Rats selectively bred for alcohol preference (alcohol preferring or "P" line) have enhanced responsiveness to the low dose reinforcing effects of alcohol, less aversion to moderate/high doses of alcohol, and are able to develop tolerance to the aversive effects of alcohol more rapidly and to maintain tolerance longer than rats selectively bred for alcohol nonpreference (alcohol nonpreferring or NP might be expected to foster and maintain alcohol drinking. Weaker aversion to the pharmacological effects of moderate/high doses of alcohol in the P line would allow P rats to drink more alcohol than NP rats before the postingestional effects become aversive. Rapid induction of tolerance to the aversive effects of alcohol with repeated bouts of voluntary alcohol drinking, as well as persistence of alcohol tolerance in rats of the P line might serve to maintain alcohol drinking. These are powerful mechanisms that may serve to promote and maintain a high alcohol drinking behavior. Although these rat lines have been used to address several characteristics of excessive alcohol consumption in humans, they have not yet been used to model several aspects of human alcohol use disorders. New applications of these selectively bred rat lines are discussed which may further our understanding of the factors contributing to alcohol abuse and alcoholism.
机译：使用选择性育种产生用于酒精滥用和酒精中毒研究的动物模型代表了酒精研究领域的重大进展之一。为酒精偏爱和非酒精偏爱而选择性繁殖的大鼠对于酒精研究界的临床前和临床研究人员均有用，可用于研究饮酒的行为，神经生物学和分子基础，鉴定可能导致酗酒发展的基因和酒精中毒，以及评估旨在减少酒精摄入和预防酒精复发的药物的实用性。为酒精偏爱（酒精偏爱或“ P”品系）选择性繁殖的大鼠对酒精的低剂量增强作用具有增强的反应性，对中/高剂量酒精的厌恶较少，并且能够对酒精的厌恶作用产生更多的耐受性与选择性饲养不喜欢酒精的大鼠相比，它的反应迅速且维持的耐受性更长（可以预期不喜欢酒精或NP可以促进和维持饮酒。对P系中量/高剂量酒精的药理作用的厌恶会使P大鼠在出现不良反应之前，要比NP大鼠喝更多的酒精。反复多次自愿饮酒会迅速诱导出对酒精的厌恶作用的耐受性，以及P系大鼠的持续酒精耐受性可能有助于维持饮酒这些强大的机制可能有助于促进和维持高饮酒行为。已将大鼠品系用于解决人类过度饮酒的几个特征，但尚未用于对人类饮酒障碍的几个方面进行建模。讨论了这些选择性繁殖的大鼠品系的新应用，这可能会使我们进一步了解导致酗酒和酗酒的因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号