...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Spectroscopy Letters >Comparative study of the ratio spectra derivative spectrophotometry, derivative spectrophotometry and Vierordt's method applied to the analysis of lisinopril and hydrochlorthiazide in tablets
【24h】

Comparative study of the ratio spectra derivative spectrophotometry, derivative spectrophotometry and Vierordt's method applied to the analysis of lisinopril and hydrochlorthiazide in tablets

机译：比率光谱导数分光光度法，导数分光光度法和Vierordt方法用于分析片剂中赖诺普利和盐酸噻嗪的比较研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Three new spectrophotometric methods are described for the determination of lisinopril and hydrochlorthiazide in their binary mixture: First derivative spectrophotometry,ratio spectra derivative and Vierordt's method. The procedures do not require any prior separation. In the derivative spectrophotometry, the dAld lambda values in the first derivative spectra of the mixture were measured at 289.6 nm for lisinopril and at 279.8 nm for hydrochlorthiazide. The calibration graphs were linear in the range 25.56-129.50 mu g.ml(-1) for lisinopril and 10.60-139.50 mu g.ml(-1) for hydrochlorothiazide. In ratio spectra derivative spectrophotometry, the calibration graphs for 15.88-129.50 mu g.ml(-1) lisinopril and for 5.98-139.80 mu g.ml(-1) hydrochlorothiazide were obtained by measuring the signals at 253.7 nm and 243.6 nm for lisinopril and at 280.1 nm and 270.8 nm for hydrochlorothiazide. In Vierordt's method, A(1)(1) (1%, 1 cm) values of lisinopril and hydrochlorthiazide were determined at 259.8 nm and 272.7 nm in the zero - order spectra. The quantity of both compounds were calculated by using the A(1)(1) (1%, 1 cm) values. The methods were successfully applied to a pharmaceutical formulation for determination of both active compounds. [References: 19]
机译：介绍了测定赖诺普利和盐酸噻嗪类二元混合物中三种新的分光光度法：一阶导数分光光度法，比值光谱导数法和维耶德方法。该程序不需要任何事先分离。在导数分光光度法中，对于赖诺普利，在289.6 nm下测定混合物的一阶导数光谱中的dAldλ值;对于氢噻嗪，在279.8 nm上测定的值。赖诺普利的校准曲线是线性的，范围为25.56-129.50μg.ml（-1），氢氯噻嗪的校准曲线为10.60-139.50μg.ml（-1）。在比率光谱导数分光光度法中，通过测量赖诺普利在253.7 nm和243.6 nm处的信号，获得了15.88-129.50μg.ml（-1）赖诺普利和5.98-139.80μg.ml（-1）氢氯噻嗪的校准图。氢氯噻嗪在280.1 nm和270.8 nm处。用Vierordt方法，在零级光谱中，赖诺普利和盐酸噻嗪的A（1）（1）（1％，1 cm）值分别在259.8 nm和272.7 nm处测定。通过使用A（1）（1）（1％，1 cm）值计算两种化合物的量。该方法已成功应用于确定两种活性化合物的药物制剂。 [参考：19]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号