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首页> 外文期刊>Stroke: A Journal of Cerebral Circulation >Stroke prevention therapy beyond antithrombotics: unifying mechanisms in ischemic stroke pathogenesis and implications for therapy: an invited review.
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Stroke prevention therapy beyond antithrombotics: unifying mechanisms in ischemic stroke pathogenesis and implications for therapy: an invited review.

机译：除抗血栓形成药物以外的中风预防疗法：缺血性中风发病机理的统一机制及其对治疗的意义：特邀评论。

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BACKGROUND: It is estimated that about half of cardiovascular disease risk is explained by conventional risk factors. The realization that atherosclerosis is an inflammatory disease has led to a search for new stroke and cardiovascular disease risk factors and treatments. As such, the vulnerable atherosclerotic plaque has become the main focus for new medical strategies for plaque stabilization and stroke prevention. SUMMARY OF REVIEW: In this invited review, I discuss inflammation as a possible risk factor for stroke, unifying mechanisms in ischemic stroke pathogenesis, and new avenues for stroke prevention---statin agents, angiotensin-converting enzyme inhibitors, and vitamins. These new stroke prevention therapies may help to reduce inflammation, serve to stabilize the atherosclerotic plaque, or act by other protective mechanisms. CONCLUSION: Beyond the traditional antithrombotic agents, statin agents, angiotensin-converting enzyme inhibitors, and vitamins may prove to be important additions to our armamentarium for stroke prevention.
机译：背景：据估计，约有一半的心血管疾病风险是由常规风险因素解释的。动脉粥样硬化是一种炎症性疾病的认识导致人们寻找新的中风和心血管疾病的危险因素和治疗方法。这样，易损的动脉粥样硬化斑块已经成为用于斑块稳定和预防中风的新医学策略的主要焦点。综述：在本受邀的综述中，我讨论了炎症作为中风的可能危险因素，统一了缺血性中风发病机制，以及预防中风的新途径-他汀类药物，血管紧张素转换酶抑制剂和维生素。这些新的中风预防疗法可能有助于减轻炎症，稳定动脉粥样硬化斑块或通过其他保护机制发挥作用。结论：除了传统的抗血栓形成剂外，他汀类药物，血管紧张素转化酶抑制剂和维生素可能被证明是我们预防卒中的重要补充。

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