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首页> 外文期刊>Stroke: A Journal of Cerebral Circulation >Demographic and geographic vascular risk factor differences in european young adults with ischemic stroke: The 15 cities young stroke study
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Demographic and geographic vascular risk factor differences in european young adults with ischemic stroke: The 15 cities young stroke study

机译：欧洲年轻人缺血性卒中的人口统计学和地理血管危险因素差异：15个城市的年轻人中风研究

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BACKGROUND AND PURPOSE-: We compared among young patients with ischemic stroke the distribution of vascular risk factors among sex, age groups, and 3 distinct geographic regions in Europe. METHODS-: We included patients with first-ever ischemic stroke aged 15 to 49 years from existing hospital- or population-based prospective or consecutive young stroke registries involving 15 cities in 12 countries. Geographic regions were defined as northern (Finland, Norway), central (Austria, Belgium, France, Germany, Hungary, The Netherlands, Switzerland), and southern (Greece, Italy, Turkey) Europe. Hierarchical regression models were used for comparisons. RESULTS-: In the study cohort (n=3944), the 3 most frequent risk factors were current smoking (48.7%), dyslipidemia (45.8%), and hypertension (35.9%). Compared with central (n=1868; median age, 43 years) and northern (n=1330; median age, 44 years) European patients, southern Europeans (n=746; median age, 41 years) were younger. No sex difference emerged between the regions, male:female ratio being 0.7 in those aged <34 years and reaching 1.7 in those aged 45 to 49 years. After accounting for confounders, no risk-factor differences emerged at the region level. Compared with females, males were older and they more frequently had dyslipidemia or coronary heart disease, or were smokers, irrespective of region. In both sexes, prevalence of family history of stroke, dyslipidemia, smoking, hypertension, diabetes mellitus, coronary heart disease, peripheral arterial disease, and atrial fibrillation positively correlated with age across all regions. CONCLUSIONS-: Primary preventive strategies for ischemic stroke in young adults-having high rate of modifiable risk factors-should be targeted according to sex and age at continental level.
机译：背景与目的：我们比较了欧洲缺血性卒中的年轻患者在性别，年龄组和3个不同地理区域中血管危险因素的分布。方法：我们纳入了来自12个国家/地区15个城市的现有以医院或人群为基础的前瞻性或连续性年轻卒中登记簿，首次出现15至49岁的缺血性卒中患者。地理区域被定义为欧洲北部（芬兰，挪威），中部（奥地利，比利时，法国，德国，匈牙利，荷兰，瑞士）和南部（希腊，意大利，土耳其）。层次回归模型用于比较。结果-：在研究队列（n = 3944）中，三个最常见的危险因素是当前吸烟（48.7％），血脂异常（45.8％）和高血压（35.9％）。与欧洲中部患者（n = 1868;中位年龄43岁）和北部（n = 1330;中位年龄44岁）相比，欧洲南部患者（n = 746;中位年龄41岁）年轻。区域之间没有性别差异，<34岁的男女比例为0.7，而45至49岁的男女比例为1.7。在考虑了混杂因素之后，在区域一级没有出现风险因素差异。与女性相比，男性年龄更大，他们血脂异常或冠心病的发病率更高，或者吸烟者，无论其身在何处。在所有性别中，所有地区的中风，血脂异常，吸烟，高血压，糖尿病，冠心病，外周动脉疾病和房颤的家族史患病率均与年龄成正相关。结论-：应根据大陆地区的性别和年龄，针对年轻人（具有较高的可改变的危险因素）预防缺血性卒中的主要策略。

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