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Incidence, risk, management, and outcomes of iatrogenic full-thickness large bowel injury associated with 56,882 colonoscopies in 14 Lithuanian hospitals

机译:立陶宛14家医院因医源性全层大肠损伤与56,882例结肠镜检查相关的发生率,风险,管理和结局

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Background: The primary goal of this hospital-based retrospective multicenter case series study was to determine the incidence of large bowel full-thickness injury associated with colonoscopy in Lithuania. We assessed characteristics of patients who were treated as a result of this complication; management and outcomes were the secondary goals of this study. Methods: The medical records of patients with iatrogenic large bowel perforations resulting from colonoscopy within the period January 1, 2007, to December 31, 2011, were retrospectively reviewed. Representatives of 14 Lithuanian public and private hospitals participated in the survey. Results: A total of 56,882 colonoscopies were performed. Forty patients (23 female and 17 male patients) were reported to have iatrogenic full-thickness large bowel injury. Diagnostic and therapeutic colonoscopies resulted in perforation for 28 of 49,795 patients and 12 of 7,087 patients, respectively. A mean age of 70 years and a female preponderance for this complication was revealed. Sigmoid colon and rectosigmoid junction was perforated in 28 patients. All patients underwent surgical management, either primary repair (70.0 %) or bowel resection (30.0 %). Postoperative complications were diagnosed in 15 patients. Immediate treatment resulted in fewer intestinal resections and shorter hospital stays (p < 0.05). Smoking [odds ratio (OR) 14.4, 95 % confidence interval (CI) 1.16-179.8] and a large size perforation site (15 ± 10 vs. 8 ± 5 mm; OR 1.19, 95 % CI 1.03-1.38) were risk factors for developing a postoperative complication after curative surgery. Six patients died. All deaths were related to diagnostic colonoscopy. Conclusions: Total incidence of large bowel full-thickness injury in Lithuanian hospitals is 0.07 %. Incidence of this complication after diagnostic and therapeutic colonoscopies is 0.056 and 0.169 %, respectively. The most common site of perforation is sigmoid colon and rectosigmoid junction, at 70 %. Risk rises when colonoscopy is performed in low-volume practice centers. Urgent surgical management resulted in overall mortality rate of 15.0 % and morbidity of 37.5 %.
机译:背景:这项基于医院的回顾性多中心病例系列研究的主要目标是确定立陶宛与结肠镜检查相关的大肠全层损伤的发生率。我们评估了由于这种并发症而接受治疗的患者的特征。管理和结果是本研究的次要目标。方法:回顾性分析2007年1月1日至2011年12月31日因结肠镜检查导致的医源性大肠穿孔的患者的病历。立陶宛14家公立和私立医院的代表参加了调查。结果:共进行了56,882例结肠镜检查。据报道有40例患者(23例女性和17例男性患者)患有医源性全层大肠损伤。诊断性和治疗性结肠镜检查分别导致49,795例患者中的28例和7,087例患者中的12例穿孔。揭示出平均年龄为70岁,女性为这种并发症的优势。乙状结肠和直肠乙状结肠连接处穿孔28例。所有患者均接受了外科手术治疗,即初次修复(70.0%)或肠切除术(30.0%)。 15例患者被诊断出术后并发症。立即治疗可减少肠切除和缩短住院时间(p <0.05)。吸烟[优势比(OR)14.4,95%置信区间(CI)1.16-179.8]和较大的穿孔部位(15±10 vs. 8±5 mm; OR 1.19,95%CI 1.03-1.38)是危险因素用于根治性手术后的术后并发症。 6例患者死亡。所有死亡均与结肠镜诊断有关。结论:立陶宛医院大肠全层损伤的总发生率为0.07%。在诊断和治疗结肠镜检查后,该并发症的发生率分别为0.056%和0.169%。最常见的穿孔部位是乙状结肠和直肠乙状结肠交界处,占70%。在小批量执业中心进行结肠镜检查时,风险会增加。紧急的外科治疗导致总死亡率为15.0%,发病率为37.5%。

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