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首页> 外文期刊>Surgical Endoscopy >Effects of preoperative exposure to a high-fat versus a low-fat diet on ingestive behavior after gastric bypass surgery in rats.
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Effects of preoperative exposure to a high-fat versus a low-fat diet on ingestive behavior after gastric bypass surgery in rats.

机译：术前高脂和低脂饮食对大鼠胃搭桥手术后摄食行为的影响。

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The consumption of high fat and sugar diets is decreased after gastric bypass surgery (GB). The mechanisms remain unclear, with tests of motivated behavior toward fat and sugar producing conflicting results in a rat model. These discrepancies may be due to differences in presurgical maintenance diets. The authors used their GB rat model to determine whether the fat content of preoperative maintenance diets affects weight loss, calorie intake, and macronutrient selection after surgery.Male Wistar rats were either low-fat diet fed (LFDF) with normal chow or high-fat diet fed (HFDF) before randomization to GB or sham surgery. In food preference test 1, the animals were offered the choice of a vegetable drink (V8) or a high-calorie liquid (Ensure), and in food preference test 2, they could choose normal chow or a solid high-fat diet.The GB groups did not differ significantly in terms of body weight loss or caloric intake. In food preference test 1, both groups responded similarly by reducing their preference for Ensure and increasing their preference for V8. In food preference test 2, the HFDF-GB rats reduced their preference for a solid high-fat diet gradually compared with the immediate reduction observed in the LFDF-GB rats.The consumption of presurgical maintenance diets with different fat contents did not affect postoperative weight loss outcomes. Both the LFDF-GB and HFDF-GB rats exhibited behaviors consistent with the possible expression of a conditioned taste aversion to a high-fat stimulus. These results suggest that for some physiologic parameters, low-fat-induced obesity models can be used for the study of changes after GB and have relevance to many obese humans who consume high-calorie but low-fat diets.
机译：胃搭桥手术（GB）后，高脂肪和高糖饮食的消耗减少了。机制尚不清楚，在老鼠模型中对脂肪和糖的动机行为的测试产生了矛盾的结果。这些差异可能是由于术前维持饮食的差异造成的。作者使用他们的GB大鼠模型来确定术前维持饮食的脂肪含量是否会影响手术后的体重减轻，卡路里摄入和大量营养素的选择。雄性Wistar大鼠采用低脂饮食（LFDF）正常饮食或高脂饮食在随机分配至GB或假手术之前先进行饮食喂养（HFDF）。在食物偏好测试1中，为动物提供了选择蔬菜饮料（V8）或高热量液体（确保）的选择，在食物偏好测试2中，动物可以选择普通的食物或固体高脂饮食。 GB组在体重减轻或热量摄入方面无显着差异。在食物偏爱测试1中，两组的反应相似，减少了对“保证”的偏爱并增加了对V8的偏爱。在食物偏好测试2中，与LFDF-GB大鼠所观察到的立即降低相比，HFDF-GB大鼠逐渐降低了对固体高脂饮食的偏好。食用具有不同脂肪含量的术前维持饮食并不影响术后体重损失结果。 LFDF-GB和HFDF-GB大鼠均表现出与高脂刺激条件化厌恶情绪表达可能一致的行为。这些结果表明，对于某些生理参数，低脂诱导的肥胖模型可用于研究GB后的变化，并且与许多食用高热量但低脂饮食的肥胖人群有关。

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