• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Surgical Endoscopy >Colonic architectural change on colonoscopy in patients taking psychotropic medications
【24h】

Colonic architectural change on colonoscopy in patients taking psychotropic medications

机译：服用精神药物的患者在结肠镜检查中结肠结构的变化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Patients on psychotropic medications have been clinically observed to have higher rates of abnormal colonic architecture resulting in difficult colonoscopies. This study aims to determine if a correlation between use of psychotropic medications and colonic architectural change seen on colonoscopy exists. Methods: A retrospective case-control study was undertaken with 252 adults selected from the hospital endoscopy database between January 2006 and July 2008. Cases were selected if they had 'capacious', 'megacolon', 'redundant' and/or 'featureless' colonic architecture reported in their first completed colonoscopy (n = 63). Demographic information and medication records were collected for both cases and controls. Logistic regression analysis was performed for each of the medication groups. Results: Medication groups associated with increased incidence for colonic architectural changes observed during colonoscopy include: antipsychotic medications [odds ratio (OR) 7.79, confidence interval (CI) 2.59-23.41], benzhexol (OR 23.50, CI 2.83-195.08) and iron tablets (OR 2.97, CI 1.39-6.33). Antidepressants, laxatives, benzodiazepines, gastroprotective medications and antihypertensive medications were not found to have any significant effect on changes to colonic architecture. Conclusions: Use of antipsychotic medications is associated with changes to colonic architecture. This could predispose such a patient to difficult colonoscopy and therefore increase colonoscopy-associated risks. Medication history should be elicited prior to colonoscopy.
机译：背景：临床上已观察到使用精神药物的患者结肠结构异常的发生率较高，导致结肠镜检查困难。这项研究旨在确定精神药物的使用与结肠镜检查所见的结肠结构改变之间是否存在相关性。方法：回顾性病例对照研究于2006年1月至2008年7月间从医院内窥镜数据库中选择了252名成年人。选择了具有“大容量”，“巨结肠”，“多余”和/或“无特征”结肠的病例他们的首次完成的结肠镜检查报告了其结构（n = 63）。收集了病例和对照的人口统计学信息和用药记录。对每个药物组进行逻辑回归分析。结果：与在结肠镜检查过程中观察到的结肠结构改变发生率增加相关的药物组包括：抗精神病药物[比值比（OR）7.79，置信区间（CI）2.59-23.41]，苯扎克索（OR 23.50，CI 2.83-195.08）和铁片（或2.97，CI 1.39-6.33）。未发现抗抑郁药，泻药，苯并二氮杂gas，胃保护药和降压药对结肠结构的改变没有显着影响。结论：抗精神病药的使用与结肠结构的改变有关。这可能会使这类患者难以进行结肠镜检查，因此会增加结肠镜检查相关的风险。结肠镜检查前应明确用药史。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号