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首页> 外文期刊>Surgical Endoscopy >Evaluating outcomes of endoscopic full-thickness plication for gastroesophageal reflux disease (GERD) with impedance monitoring.
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Evaluating outcomes of endoscopic full-thickness plication for gastroesophageal reflux disease (GERD) with impedance monitoring.

机译：通过阻抗监测评估内镜全厚度皱plication治疗胃食管反流病（GERD）的结果。

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BACKGROUND: Endoscopic full-thickness plication allows transmural suturing at the gastroesophageal junction to recreate the antireflux barrier. Multichannel intraluminal impedance monitoring (MII) can be used to detect nonacid or weakly acidic reflux, acidic swallows, and esophageal clearance time. This study used MII to evaluate the outcome of endoscopic full-thickness plication. METHODS: In this study, 12 subsequent patients requiring maintenance proton pump inhibitor therapy underwent endoscopic full-thickness plication for treatment of gastroesophageal reflux disease. With patients off medication, MII was performed before and 6-months after endoscopic full-thickness plication. RESULTS: The total median number of reflux episodes was significantly reduced from 105 to 64 (p = 0.016). The median number of acid reflux episodes decreased from 73 to 43 (p = 0.016). Nonacid reflux episodes decreased from 23 to 21 (p = 0.306). The median bolus clearance time was 12 s before treatment and 11 s at 6 months (p = 0.798). The median acid exposure time was reduced from 6.8% to 3.4% (p = 0.008), and the DeMeester scores were reduced from 19 to 12 (p = 0.008). CONCLUSION: Endoscopic full-thickness plication significantly reduced total reflux episodes, acid reflux episodes, and total reflux exposure time. The DeMeester scores and total acid exposure time for the distal esophagus were significantly improved. No significant changes in nonacid reflux episodes and median bolus clearance time were encountered.
机译：背景：内窥镜全厚度折叠允许在胃食管连接处进行透壁缝合以重建抗反流屏障。多通道腔内阻抗监测（MII）可用于检测非酸性或弱酸性回流，酸性吞咽和食道清除时间。这项研究使用MII来评估内镜全层折叠的结果。方法：在本研究中，随后的12例需要维持质子泵抑制剂治疗的患者接受内镜全层折叠治疗胃食管反流病。在患者不使用药物的情况下，在进行内镜全层折叠之前和之后的6个月进行MII。结果：反流发作的总中位数从105个明显减少到64个（p = 0.016）。胃酸反流发作的中位数从73降至43（p = 0.016）。非酸反流发作从23降低到21（p = 0.306）。中药团清除时间为治疗前12 s，6个月为11 s（p = 0.798）。中位酸暴露时间从6.8％降低到3.4％（p = 0.008），DeMeester评分从19降低到12（p = 0.008）。结论：内窥镜全厚度折叠显着减少了总反流发作，酸性反流发作和总反流暴露时间。远端食管的DeMeester评分和总酸暴露时间得到显着改善。在非酸性反流发作和大剂量推注清除时间方面未见明显变化。

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