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首页> 外文期刊>Surgical Endoscopy >A novel endoscopic fluorescent clip for the localization of gastrointestinal tumors.
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A novel endoscopic fluorescent clip for the localization of gastrointestinal tumors.

机译：用于胃肠道肿瘤定位的新型内窥镜荧光夹。

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BACKGROUND: Accurate tumor localization is essential for gastrointestinal surgery, especially in cases of early cancer. This study was designed to develop a novel fluorescent clip for rapid and exact visualization of tumor sites. METHODS: A transparent polymer matrix containing highly bright fluorochromes was coated on the front end of endoscopic clips. The fluorescent clips were placed on the mucosal surface of a porcine colon and stomach, and the operator then attempted to identify the fluorescent clips from the outer serosal side of the colon and stomach. A 532-nm diode laser and filter glass were used for visualizing the fluorescence signals through the colonic tissue. A 650-nm diode laser and a digital charge-coupled device (CCD) camera equipped with a bandpass emission filter were used for the imaging of the fluorescent clips through the thick stomach tissue. RESULTS: When a green light from a 532-nm diode laser (power density=0.35 mW/cm2) was applied on the serosal surface of the porcine colon, we could identify all clips that had been placed endoscopically on the mucosal surface of the inner colonic wall. By using the light from a 650-nm diode laser (power density=0.7 mW/cm2), we identified all fluorescent clips through the stomach wall in real time. Similar results were also obtained with the filtered xenon lamp. CONCLUSION: An endoscopic fluorescent clip can be useful for the rapid and exact localization of tumors, and this technique can also be useful during laparoscopic surgery.
机译：背景：准确的肿瘤定位对于胃肠外科手术至关重要，尤其是在早期癌症的情况下。这项研究旨在开发一种新型荧光夹，用于快速准确地可视化肿瘤部位。方法：在内窥镜夹子的前端涂上一层含有高亮度荧光染料的透明聚合物基体。将荧光片段放置在猪结肠和胃的粘膜表面，然后操作者尝试从结肠和胃的浆膜外侧识别荧光片段。使用532 nm的二极管激光器和滤镜来观察通过结肠组织的荧光信号。配备有带通发射滤光片的650 nm二极管激光器和数字电荷耦合器件（CCD）相机用于穿过厚胃组织的荧光夹成像。结果：当将532 nm二极管激光器发出的绿光（功率密度= 0.35 mW / cm2）施加到猪结肠的浆膜表面时，我们可以识别出所有在内窥镜下放置在内部粘膜表面上的夹子结肠壁。通过使用650 nm二极管激光器发出的光（功率密度= 0.7 mW / cm2），我们可以实时识别出穿过胃壁的所有荧光夹。用过滤的氙气灯也获得了类似的结果。结论：内窥镜荧光夹可用于快速准确地定位肿瘤，该技术在腹腔镜手术中也可使用。

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