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首页> 外文期刊>Surgical Endoscopy >Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a single-center experience.
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Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a single-center experience.

机译：内镜黏膜下剥离术治疗早期胃癌的长期结果：单中心经验。

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摘要

In Korea, endoscopic submucosal dissection (ESD) has been widely accepted for the treatment of early gastric cancers (EGCs). However, the understanding of the long-term clinical outcome of ESD for EGC remains insufficient. Therefore, the aim of the present study was to assess the long-term clinical outcome and efficacy of ESD for the treatment of EGCs, including the clinical application of the expanded criteria for ESD.From January 2006 to December 2010, a total of 515 patients with 522 EGCs were treated by ESD in our hospital; study enrollment was based on the expanded criteria. Comparisons of resectability (en bloc or piecemeal resection), curability (curative or non-curative), and complications (bleeding and perforation) between the standard and expanded groups were assessed. Thereafter, 336 patients with 342 EGCs were finally included in a long-term analysis of local tumor recurrence, development of synchronous and metachronous cancers, and overall and disease-specific survival rates.En bloc and curative resection rates of 96.7 % and 88.3 %, respectively, were achieved. The curative resection rate was significantly lower in the expanded group than in the standard group (82.1 % vs. 91.5 %, p = 0.001). During a median follow-up of 24 months, the local tumor recurrence rate was also higher in the expanded group than in the standard group (7.0 % vs. 1.8 %, p = 0.025). Local recurrence was more frequent in lesions with non-curative resection than in those with curative resection (20.0 % vs. 1.3 %, p < 0.001). The 5-year overall and disease-specific survival rates were 88 % and 100 %, respectively; the difference between the standard and expanded groups was not significant (p = 0.834).ESD appears to be a feasible and effective method for treating EGCs, based on the standard and expanded criteria. Close follow-up surveillance, after ESD, should be standard for all patients.
机译：在韩国，内镜下黏膜下剥离术（ESD）已被广泛接受用于治疗早期胃癌（EGC）。然而，对于EGC的ESD长期临床结果的了解仍然不足。因此，本研究的目的是评估ESD治疗EGC的长期临床结果和疗效，包括扩展ESD标准的临床应用.2006年1月至2010年12月，共有515例患者我院对522例EGC进行了ESD治疗;研究入组依据的是扩展的标准。评估了标准组和扩展组之间可切除性（整体切除或逐块切除），可治愈性（治愈性或非治愈性）以及并发症（出血和穿孔）的比较。此后，对336例342个EGC的患者进行了长期分析，最终纳入了局部肿瘤复发，同期和异时癌症的发展以及总体和疾病特异性生存率的长期分析。整群和治愈性切除率为96.7％和88.3％，分别实现。扩大组的治愈率明显低于标准组（82.1％vs. 91.5％，p = 0.001）。在24个月的中位随访期间，扩展组的局部肿瘤复发率也高于标准组（7.0％vs. 1.8％，p = 0.025）。与非根治性切除相比，非根治性切除的局部复发率更高（20.0％vs. 1.3％，p <0.001）。 5年总生存率和疾病特异性生存率分别为88％和100％。标准组和扩展组之间的差异不显着（p = 0.834）。根据标准和扩展标准，ESD似乎是一种可行且有效的治疗EGC的方法。 ESD后，密切随访监测应成为所有患者的标准。

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