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首页> 外文期刊>Surgical Endoscopy >Laparoscopic radiofrequency ablation of unresectable hepatic malignancies. A phase 2 trial.
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Laparoscopic radiofrequency ablation of unresectable hepatic malignancies. A phase 2 trial.

机译：不可切除的肝恶性肿瘤的腹腔镜射频消融术。 2期试验。

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BACKGROUND: Radiofrequency ablation (RFA) of hepatic malignancies has been performed successfully via a percutaneous route or at laparotomy. We analyzed the efficacy and utility of laparoscopic intraoperative ultrasound and RFA in patients with unresectable hepatic malignancies. METHODS: Between November 1997 and November 1999, 27 patients with unresectable hepatic malignancies and no evidence of extrahepatic disease were entered in a phase 2 trial of laparoscopic intraoperative ultrasound and RFA. Real-time ultrasonography was used to guide RFA, and lesions were ablated at a temperature of 100 degrees C for 10 min. Overlapping ablations were performed for larger lesions. RESULTS: Additional tumors were identified in 10 (37%) of the 27 study patients by laparoscopy and laparoscopic intraoperative ultrasound despite extensive preoperative imaging. Radiofrequency ablation of 85 hepatic tumors yielded no mortality and only one case of postoperative bleeding. During a mean follow-up period of 14 months, four tumors (4.7%) locally recurred. Of the 27 patients, 11 (41%) remain free of disease at this writing; (22%) are alive with disease; and 10 (37%) have died with disease. CONCLUSION: Laparoscopic RFA and intraoperative ultrasound constitute a safe and accurate method for ablation of unresectable hepatic tumors.
机译：背景：肝恶性肿瘤的射频消融（RFA）已通过经皮途径或剖腹手术成功完成。我们分析了腹腔镜术中超声和RFA在无法切除的肝恶性肿瘤患者中的疗效和实用性。方法：在1997年11月至1999年11月期间，在腹腔镜术中超声和RFA的2期试验中纳入了27例不可切除的肝恶性肿瘤且无肝外疾病证据的患者。实时超声检查用于指导RFA，并在100摄氏度的温度下消融病变10分钟。对较大的病变进行重叠消融。结果：尽管术前进行了广泛的影像检查，但通过腹腔镜和腹腔镜术中超声在27例研究患者中有10例（37％）发现了其他肿瘤。射频消融治疗85例肝肿瘤无死亡，仅1例术后出血。在平均14个月的随访期间，局部复发了4个肿瘤（4.7％）。在本文撰写的27例患者中，有11例（41％）没有疾病; （22％）还活着。有10人（37％）死于疾病。结论：腹腔镜RFA和术中超声检查是消融不可切除的肝肿瘤的一种安全，准确的方法。

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