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首页> 外文期刊>Surgical Endoscopy >Effects of helium pneumoperitoneum in pregnant ewes.
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Effects of helium pneumoperitoneum in pregnant ewes.

机译：氦气气腹对孕妇母羊的影响。

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BACKGROUND: Previous animal studies have demonstrated that a carbon dioxide (CO(2)) pneumoperitoneum in pregnant ewes causes maternal and fetal acidosis, decreased uterine blood flow (UtBF), and fetal hypertension. This study was undertaken to determine whether helium (He) produces these same effects when used as an insufflating gas. METHODS: Six gravid ewes, at 116 to 120 days gestation, underwent catheterization of the maternal femoral artery and vein and the fetal hindlimb artery and vein, as well as insertion of a uterine artery flow probe. After a 6-day recovery period, the animals were anesthetized; a Hasson trocar was placed; and an He pneumoperitoneum was established (10 mmHg for 30 min followed by 15 mmHg for 30 min). The following parameters were recorded at baseline and at preset time points: maternal and fetal heart rate (HR), blood pressure (BP), arterial blood gasses, maternal end-tidal CO(2) (EtCO2), and UtBF. The percentage of change over time was determined for each variable. The results were compared with results previously obtained in control animals and in animals undergoing CO(2) pneumoperitoneum. Statistical significance was determined by repeated measures analysis of variance (ANOVA). RESULTS: The following statistically significant changes were found. CONCLUSIONS: Like CO(2), He used for pneumoperitoneum resulted in decreased UtBF and fetal hypertension because of increased intra-abdominal pressure. Unlike a CO(2), He used for pneumoperitoneum does not cause maternal or fetal acidosis, indicating that the metabolic effects seen with CO(2) are the result of the specific gas used. Therefore, He may be a safer gas than CO(2) to use for laparoscopic procedures in pregnant patients.
机译：背景：先前的动物研究表明，孕妇母羊中的二氧化碳（CO（2））气腹会引起母体和胎儿酸中毒，子宫血流减少（UtBF）和胎儿高血压。进行这项研究是为了确定氦气用作吹入气体时是否会产生这些相同的作用。方法：在妊娠116至120天时对六只妊娠母羊进行导管插入，对母体股动脉和静脉以及胎儿后肢动脉和静脉进行导管插入，并插入子宫动脉流量探针。恢复期为6天后，将动物麻醉;放置了哈森套管针;建立气腹膜（10 mmHg持续30分钟，然后15 mmHg持续30分钟）。在基线和预设时间点记录以下参数：孕妇和胎儿心率（HR），血压（BP），动脉血气，孕妇潮气末CO（2）（EtCO2）和UtBF。确定每个变量随时间的变化百分比。将该结果与先前在对照动物和进行CO（2）气腹的动物中获得的结果进行比较。通过重复测量方差分析（ANOVA）确定统计显着性。结果：发现以下统计学上的显着变化。结论：与CO（2）一样，他用于气腹导致UtBF降低和胎儿高血压，因为腹腔内压力升高。与CO（2）不同，用于气腹的He不会引起母体或胎儿酸中毒，表明CO（2）所见的代谢作用是所用特定气体的结果。因此，对于孕妇，腹腔镜手术使用的氦气可能比CO（2）更安全。

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