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首页> 外文期刊>Surgical Endoscopy >Changes in T cell subsets, interleukin-6 and C-reactive protein after laparoscopic and open colorectal resection for malignancy.
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Changes in T cell subsets, interleukin-6 and C-reactive protein after laparoscopic and open colorectal resection for malignancy.

机译：腹腔镜和大肠切除术切除恶性肿瘤后，T细胞亚群，白细胞介素6和C反应蛋白的变化。

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摘要

BACKGROUND: Attenuation of the immune response to surgery, as demonstrated with the laparoscopic approach to cholecystectomy, has potential benefits in patients undergoing laparoscopic colonic resection for malignancy. We aimed to study the perioperative immune response in patients undergoing laparoscopically assisted and open surgery for colorectal cancer. METHODS: This study involved 23 patients undergoing laparoscopically assisted (n = 13) and open surgery (n = 10). Interleukin-6 (IL-6) C-reactive protein (CRP), the total lymphocyte count, and the CD3, CD4, CD8, CD16, and CD19 lymphocyte subpopulations were assayed preoperatively and at 4, 8, 10, 24, 48, and 168 h postoperatively. RESULTS: Significant rises in IL-6 and CRP were demonstrated within 4 and 24 h, respectively (p < 0.001) in both groups. However, no significant difference between the groups was seen. Significant decreases in total lymphocyte count and all T cell subsets were demonstrated in both groups, beginning at 4 h (p < 0.01). However, no significant difference between the groups was seen. All parameters, excluding CRP, had returned to baseline by 7 days postoperatively in both groups. CONCLUSIONS: Patients with malignancy exhibit significant perioperative immune disturbance with laparoscopically assisted and open surgery. The current data do not provide justification for the laparoscopically assisted approach on grounds of immune preservation.
机译：背景：腹腔镜胆囊切除术证明了手术免疫反应的减弱，对接受腹腔镜结肠癌切除术的患者具有潜在的益处。我们旨在研究接受腹腔镜辅助和大肠癌开放手术的患者的围手术期免疫反应。方法：该研究涉及23例接受腹腔镜辅助（n = 13）和开放手术（n = 10）的患者。术前和分别在4、8、10、24、48岁时测定了白细胞介素6（IL-6）C反应蛋白（CRP），淋巴细胞总数以及CD3，CD4，CD8，CD16和CD19淋巴细胞亚群，术后168小时。结果：两组分别在4 h和24 h内均显示IL-6和CRP显着升高（p <0.001）。但是，两组之间没有显着差异。从4小时开始，两组的总淋巴细胞计数均显着下降，并且所有T细胞亚群均得到证实（p <0.01）。但是，两组之间没有显着差异。两组的所有参数（CRP除外）均在术后7天后恢复到基线。结论：恶性肿瘤患者在腹腔镜辅助和开腹手术中表现出明显的围手术期免疫紊乱。目前的数据不能为基于免疫保存的腹腔镜辅助治疗方法提供依据。

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