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An experimental model of gastroschisis using fetoendoscopy: preliminary results and technical considerations.

机译：使用胃内窥镜检查胃tro裂的实验模型：初步结果和技术考虑。

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BACKGROUND: The aim of this study was to show the feasibility of an experimental model of gastroschisis using fetoendoscopic surgery on sheep fetuses, and also to perform amnioinfusion until delivery using an in-dwelling intraamniotic catheter. METHODS: We analyzed the data from 18 pregnant ewes having 26 fetuses, which underwent surgery at 80 days of gestation (full term, 145 days). The fetendo technique was used to create a gastroschisis in 15 fetuses. The fetal abdominal wall was opened on the left side of the cord using scissors. The omentum and the intestinal loops were eviscerated using atraumatic forceps. Eleven fetuses were used as a control group. Twenty-one fetuses underwent amnioinfusion; a simple exteriorized catheter was used in seven cases and an intraamniotic catheter with an implantable port was used in the other 14. All ewes and fetuses were killed at the end of the experiment by an intravenous injection of pentotal; thereafter, the fetuses underwent necropsy. RESULTS: Twelve fetuses died and 14 survived (53.8%); seven of the 15 that underwent gastroschisis survived (46.7%). An amniotic infection occurred in nine fetuses (34.6%); of these, six died and three that were administered antibiotics survived. CONCLUSIONS: Our experience shows that this experimental model of gastroschisis is feasible and reproducible, and that a repeated amnioinfusion can be performed with an in-dwelling catheter in pregnant ewes. The use of an implantable port is safer than a simple exteriorized catheter.
机译：背景：这项研究的目的是显示使用胎儿内窥镜手术对绵羊胎儿进行胃chi裂实验模型的可行性，并进行羊膜腔输注直到使用留置羊膜内导管进行分娩。方法：我们分析了18头母羊的数据，这些母羊有26胎，在妊娠80天（足月145天）接受了手术。 fetendo技术用于在15名胎儿中产生胃裂症。用剪刀在脐带的左侧打开胎儿腹壁。大网膜和肠loop用无创伤钳切除。将11只胎儿用作对照组。 21例胎儿接受了羊膜腔灌注;在7例中，使用了简单的外部导管，在其他14例中，使用了带有可植入端口的羊膜内导管。在实验结束时，通过静脉注射戊二醛杀死所有母羊和胎儿。此后，对胎儿进行尸检。结果：12例胎儿死亡，14例存活（53.8％）;进行胃气管痉挛的15例中有7例存活（46.7％）。 9例胎儿发生羊膜感染（34.6％）。其中有6人死亡，使用抗生素的3人幸存。结论：我们的经验表明，这种胃s裂的实验模型是可行且可重现的，并且可以通过留置导管对孕妇母羊进行重复性羊膜腔灌注。植入式端口的使用比简单的外部导管更安全。

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