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首页> 外文期刊>Surgical Endoscopy >A novel endoesophageal magnetic device to prevent gastroesophageal reflux.
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A novel endoesophageal magnetic device to prevent gastroesophageal reflux.

机译：一种防止胃食管反流的新型食管内磁性装置。

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BACKGROUND: Endoscopic methods to prevent gastroesophageal reflux (GER) show scarce effectiveness and may narrow the esophageal lumen more or less stiffly, sometimes impairing bolus transit and leading to dysphagia. The aim of this study was to demonstrate the possibility of reinforcing lower esophageal sphincter (LES) tone by implanting endoluminally a magnetic device. MATERIALS AND METHODS: The device consists of two small magnetic plaques to be implanted in the submucosa close to LES with opposite polarities facing so that they attract one other, closing the esophageal lumen. The magnets were implanted by means of a special endoluminal device in five esophageal-gastric ex vivo specimens taken from swine. Variation in endoluminal pressure at the LES level was measured by means of slow pull-through of a thin side-hole manometric catheter in each specimen, before and after insertion of the magnets. RESULTS: The new high-pressure zone exhibited a length of about 2 cm and a pressure of 14.2+/-1.27 mmHg [mean +/- standard deviation (SD)], significantly (p<0.001) higher than that measured before insertion of the magnetic valve (1.5+/-0.26 mmHg). CONCLUSIONS: The present research demonstrates that it is possible to create at the LES level a dynamic closure of a value considered sufficient to prevent GER, by implanting in the esophageal submucosa of anatomical specimens a magnetic device by means of a special endoluminal probe. Once effectiveness and tolerability of magnets covered by a biocompatible sheath have been demonstrated in vivo, this device could become a simple and effective nonsurgical solution to GER.
机译：背景：内窥镜预防胃食管反流的方法疗效不佳，可能使食管内腔或多或少变硬，有时会缩短弹丸传输并导致吞咽困难。这项研究的目的是证明通过在腔内植入磁性装置来增强食管下括约肌（LES）音调的可能性。材料与方法：该设备由两个小的磁性斑块组成，这些斑块将被植入LES附近的粘膜下层，并且极性相反，以使它们彼此吸引，从而闭合食道管腔。通过特殊的腔内装置将磁体植入从猪身上采集的五个食管胃离体标本中。在插入磁体之前和之后，通过在每个样本中缓慢穿通薄侧孔测压导管来测量LES水平的腔内压力变化。结果：新的高压区的长度约为2厘米，压力为14.2 +/- 1.27 mmHg [平均+/-标准偏差（SD）]，显着（p <0.001）高于插入之前的测量值。电磁阀（1.5 +/- 0.26 mmHg）。结论：本研究表明，通过在特殊标本内腔探针中将磁性装置植入解剖标本的食道粘膜下，可以在LES水平上建立一个足以防止GER的值的动态闭合。一旦在体内证明了被生物相容性护套覆盖的磁体的有效性和耐受性，该设备将成为GER的一种简单有效的非手术解决方案。

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