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首页> 外文期刊>Surgical Endoscopy >Variant Creutzfeldt-Jakob disease: a cause for concern. Review of the evidence for risk of transmission through abdominal lymphoreticular tissue surgery.
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Variant Creutzfeldt-Jakob disease: a cause for concern. Review of the evidence for risk of transmission through abdominal lymphoreticular tissue surgery.

机译：Creutzfeldt-Jakob变异病：值得关注的原因。回顾腹部淋巴网状组织手术传播风险的证据。

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BACKGROUND: Concern has long existed regarding the possible iatrogenic spread of variant Creutzfeldt-Jakob disease (v-CJD) through surgery. This had been fueled by recent reports of bovine spongiform encephalopathy in U.S. cattle and the first probable case of blood transmission of v-CJD in the UK. METHODS: Systematic review of experimental and nonexperimental studies. Studies identified from searches of Medline, Embase, Cochrane Library, Science Citation Index medical databases, searching bibliographies of retrieved papers, and personal communication with international experts in the field. RESULTS: Six articles satisfied our search criteria. Evidence stems from case reports, case series, and cross-sectional studies. There are no published cases of surgically transmitted v-CJD. CONCLUSION: We found evidence of v-CJD prion agents in the spleen, appendix, rectum, and adrenal glands of affected patients and evidence of v-CJD prion in the appendix of patients in the preclinical stage of the disease. The risk of transmission of v-CJD prion during abdominal surgery is currently unquantifiable.
机译：背景：长期以来，人们对通过外科手术传播变异型克雅氏病（v-CJD）的可能的医源性关注一直存在。最近在美国牛中发生的牛海绵状脑病和英国首例可能通过v-CJD传播血液的报道助长了这种情况。方法：系统评价实验和非实验研究。通过对Medline，Embase，Cochrane图书馆，Science Citation Index医学数据库的搜索，对检索到的论文的书目搜索以及与该领域国际专家的私人交流来确定研究结果。结果：六篇文章符合我们的搜索条件。证据来自病例报告，病例系列和横断面研究。目前尚无手术传播v-CJD的病例报道。结论：我们在患病患者的脾脏，阑尾，直肠和肾上腺中发现了v-CJD ion病毒的证据，在该疾病的临床前期患者的阑尾中发现了v-CJD ion病毒的证据。目前尚无法确定在腹部手术期间传播v-CJD pr病毒的风险。

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