...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Surgical Endoscopy >A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes.
【24h】

A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes.

机译：一种使用手持式PETβ和γ探针术中定位抗体靶向的癌症沉积物的新方法。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Assessing cancer margins, lymph nodes, and small cancer deposits intraoperatively can be challenging. A new device has become available that allows the detection of positron emission tomography (PET) radiotracers through both high-energy gamma and short-range beta emissions. These PET probes are handheld, allowing for real-time evaluation of cancer using a tool that provides surgeons with better intraoperative assessment of tumor sites. METHODS: Within the context of two institutional review board (IRB)-approved protocols investigating new applications of antibody-labeled PET scanning, (124)I-labeled humanized monoclonal antibodies specific for colorectal cancer (huA33) and renal tumors (cG250) were constructed. Patients underwent preoperative PET scans, approximately seven days post-tracer infusion, when tumor-to-nontumor ratios were high. Suspected tumor deposits were evaluated intraoperatively with handheld beta and gamma PET probes. RESULTS: Handheld PET probes detected emissions from all tumors. Count rates from the gamma probe on tumor ranged from 48 to 306 cps, and for the beta probe ranged from 18 to 190 cps. Gamma and beta emissions exhibited a strong positive correlation. The ratio of gamma and beta counts was at least twice that of the background counts for all tumors evaluated. CONCLUSIONS: This study is the first to demonstrate the utility of beta probes for the intraoperative detection of radiolabeled antibodies targeting cancer. Importantly, the recorded beta count rates from the beta probe correlate with the count rates from the high-energy gamma probe. Furthermore, the beta probe may offer superior specificity for real-time localization of small tumor deposits, compared to gamma probes. The intraoperative portable PET probe may prove a valuable bridge to combining tumor biology and PET technology to guide surgical therapy.
机译：背景：术中评估癌的边缘，淋巴结和小癌的沉积可能具有挑战性。一种新设备已经问世，它可以通过高能伽马射线和短距离β射线发射来检测正电子发射断层扫描（PET）放射性示踪剂。这些PET探头是手持式的，可以使用一种为医生提供更好的术中肿瘤部位评估工具来实时评估癌症。方法：在两个机构审查委员会（IRB）批准的方案的背景下，研究了抗体标记的PET扫描的新应用，构建了（124）I标记的对结肠直肠癌（huA33）和肾肿瘤（cG250）具有特异性的人源化单克隆抗体。当肿瘤与非肿瘤比率高时，患者在示踪剂输注后约7天接受术前PET扫描。术中使用手持式beta和γPET探针评估了可疑的肿瘤沉积物。结果：手持式PET探针检测到所有肿瘤的排放物。 γ探针对肿瘤的计数速率范围为48到306 cps，β探针的计数速率为18到190 cps。 γ和β排放呈强正相关。对于所有评估的肿瘤，γ和β计数之比至少是本底计数的两倍。结论：本研究是首次证明β探针可在术中检测靶向癌症的放射性标记抗体的实用性。重要的是，记录的β探针的β计数率与高能伽马探针的计数率相关。此外，与γ探针相比，β探针可为小肿瘤沉积物的实时定位提供更高的特异性。术中便携式PET探头可能被证明是将肿瘤生物学与PET技术相结合以指导外科治疗的宝贵桥梁。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号