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首页> 外文期刊>Surgical Endoscopy >Hyaluronan levels during laparoscopic versus open colonic resections.
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Hyaluronan levels during laparoscopic versus open colonic resections.

机译：腹腔镜与开腹结肠切除术中的透明质酸水平。

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BACKGROUND: Plasma hyaluronan binds to fibrinogen, affecting intravascular fibrin polymerization and fibrin clot formation. It has been hypothesized that alterations in fibrin clot formation influence the risk of thromboembolism in those undergoing surgery. The aim of this study is to quantify the intravascular components, especially plasma hyaluronan levels, in laparoscopic and conventional colorectal resections that contribute to thromboembolism formation. METHODS: Prospective cohort analysis of consecutive patients which were participating in the prospective randomized multi-center trial Lapkon II comparing the long-term effects of laparoscopic and conventional resection for colon cancer. Plasma samples were obtained from 15 patients at the beginning and the end of laparoscopic or conventional colorectal resections. Concentrations and activities of tissue plasminogen activator(t-PA), plasminogen activator inhibitor type 1(PAI-1), t-PA/PAI complex, fibrinogen, d-dimers and hyaluronan were determined by using commercial enzyme-linked immunosorbent assay (ELISA) kits. RESULTS: No differences in age, sex and type of resection between the laparoscopic and conventional-surgery groups were observed. Laparoscopic procedures lasted longer (p < 0.05). Concentration and activities of t-PA, PAI-1, t-PA/PAI complex, fibrinogen and d-dimers did not vary between the two groups. Plasma hyaluronan decreased from 28.6 to 17.9 IU/ml (p < 0.05) during laparoscopic compared to conventional procedures. Plasma hyaluronan levels were significantly different at the end of operation between the two groups (p < 0.05) . CONCLUSIONS: Plasma hyaluronan levels were decreased in patients undergoing laparoscopic colorectal resections, compared to those undergoing conventional procedures. Therefore, interactions between plasma hyaluronan and fibrinogen may be lower, with a sequential decrease in fibrin polymerization, and a possibly reduced risk of deep venous thrombosis.
机译：背景：血浆透明质酸与血纤蛋白原结合，影响血管内血纤蛋白聚合和血纤蛋白凝块形成。据推测，纤维蛋白凝块形成的改变会影响那些接受手术的人血栓栓塞的风险。这项研究的目的是量化腹腔镜和常规结直肠切除术中有助于血栓栓塞形成的血管内成分，尤其是血浆透明质酸水平。方法：对参加前瞻性随机多中心试验Lapkon II的连续患者进行的前瞻性队列分析，比较了腹腔镜和常规切除术对结肠癌的长期疗效。在腹腔镜或常规结直肠切除术的开始和结束时从15例患者中获取血浆样品。使用商业酶联免疫吸附试验（ELISA）测定组织纤溶酶原激活物（t-PA），纤溶酶原激活物抑制剂1型（PAI-1），t-PA / PAI复合物，纤维蛋白原，d-二聚体和透明质酸的浓度和活性）套件。结果：腹腔镜手术组与常规手术组在年龄，性别和切除类型方面均无差异。腹腔镜手术持续时间更长（p <0.05）。两组间t-PA，PAI-1，t-PA / PAI复合物，纤维蛋白原和d-二聚体的浓度和活性无差异。与常规手术相比，腹腔镜手术中血浆透明质酸从28.6降至17.9 IU / ml（p <0.05）。两组手术结束时血浆透明质酸水平显着不同（p <0.05）。结论：与常规手术相比，腹腔镜大肠切除术患者血浆透明质酸水平降低。因此，血浆透明质酸和纤维蛋白原之间的相互作用可能较低，纤维蛋白聚合依次降低，并可能降低深静脉血栓形成的风险。

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