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首页> 外文期刊>Surgical Endoscopy >Ambulatory long-term pH monitoring in pigs.
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Ambulatory long-term pH monitoring in pigs.

机译：猪的动态pH长期监测。

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Background: pH monitoring has been established as the "gold standard" in the diagnosis of gastroesophageal reflux. Evaluation of experimental antireflux therapy should therefore also include this technique, but a suitable technique in an experimental model did not exist so far. The aim of our study was to establish a reliable method for the evaluation of an experimental reflux model in pigs. Methods: A total of 33 German Landrace pigs with an average body weight of 56 (50.2-67.2) kg were included. pH monitoring was performed before and after open cardiomyotomy in each animal. All manipulations were performed under general anesthesia. After manometric localization of the gastroesophageal high-pressure zone, a standard pH probe was inserted into the pharynx through a small needle-punctured canal on the side of the animal's snout and placed under endoscopic guidance with the proximal sensor 3 cm above the lower esophageal sphincter (LES) and the distal sensor in the stomach for reference. The harness to carry the pH recorder on the animal's back consisted of a modified belly strap that enabled the animal to move around without limitation. For analysis the same threshold levels were defined as in humans. Gastroesophageal reflux was induced by cardiomyotomy. Results: The placement of the standard pH probe was possible in all cases. Inserting the probe on the side of the snout left the animals free to nuzzle, which complies with the normal habits of pigs, without breaking the probes and without being compromised in their natural behavior. Repeated punctures for multiple measurements were easily feasible. We performed up to three examinations in each individual animal. Recording was performed for 48 h. A mean number of 67.3 (+/-9.7) acidic refluxes were registered. The mean number of long acidic refluxes was 3.2 (+/-0.75). For an average total time of 75.5 (+/-14.3) min the pH was below 4 accounting for a fraction time pH below 4 of 3.5% (+/-0.68%). Following cardiomyotomy the number of acidic refluxes increasedsignificantly to 166.1 (+/-21.8) and the number of long refluxes to 17.74 (+/-3.35). The total time of pH below 4 increased to 371.3 (+/-62) min so that the fraction time pH below 4 was 14.5% ( p = 0.0006). Conclusion: pH monitoring should be mandatory in any investigation of antireflux therapy. Our method is easy and secure to perform. It is suitable for other gastrointestinal investigations (Bilitec, long-term manometry) that could be carried out using the same technique. The described data represent the basis for other investigations of experimental antireflux therapy.
机译：背景：pH监测已被确定为胃食管反流的“金标准”。因此，对实验性抗反流疗法的评估也应包括该技术，但是到目前为止，在实验模型中还没有合适的技术。我们研究的目的是建立一种评估猪实验性反流模型的可靠方法。方法：包括33头平均体重为56（50.2-67.2）公斤的德国长白猪。在每只动物的开放式心肌切开术之前和之后进行pH监测。所有操作均在全身麻醉下进行。在对胃食管高压区进行测压定位后，将标准pH探针通过动物鼻部一侧的小针刺管插入咽中，并在内窥镜引导下置于近端传感器上方食管下括约肌上方3 cm处（LES）和胃中的远端传感器作为参考。将pH记录仪携带在动物背部的安全带由经过修饰的腹带组成，使动物可以不受限制地移动。为了进行分析，定义了与人类相同的阈值水平。胃切开术引起胃食管反流。结果：在所有情况下都可以放置标准pH探针。将探针插入口鼻的一侧可使动物自由地吃食，这符合猪的正常习惯，而不会破坏探针，也不会影响其自然行为。重复穿刺进行多次测量很容易。我们对每只动物进行了多达三项检查。记录进行48小时。记录到平均67.3（+/- 9.7）个酸性回流。长时间酸性回流的平均次数为3.2（+/- 0.75）。对于75.5（+/- 14.3）min的平均总时间，pH值低于4，说明pH值低于4的分数时间为3.5％（+/- 0.68％）。进行心肌切开术后，酸性反流次数显着增加至166.1（+/- 21.8），长反流次数增加至17.74（+/- 3.35）。 pH值低于4的总时间增加到371.3（+/- 62）min，因此pH值低于4的分数时间为14.5％（p = 0.0006）。结论：在任何抗反流治疗的研究中都应强制进行pH监测。我们的方法易于执行且安全。它适用于可以使用相同技术进行的其他胃肠道检查（Bilitec，长期测压）。所描述的数据代表了其他实验性抗反流疗法的基础。

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