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首页> 外文期刊>Surgical Endoscopy >Intravenous pantoprazole utilization in a level 1 trauma center.
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Intravenous pantoprazole utilization in a level 1 trauma center.

机译：1级创伤中心的静脉使用pan托拉唑。

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BACKGROUND: In recent years there has been a rapid increase in the use of proton pump inhibitors. Our institution has recently had several shortages of IV pantoprazole, each lasting 7-10 days. The purpose of our study was to evaluate in-patient usage of IV pantoprazole. We hypothesized that hospitalized patients with upper gastrointestinal bleeding (GIB) or risk for stress ulcers inappropriately received IV pantoprazole based on current literature. METHODS: This was a retrospective study of 165 consecutive in-patients identified as receiving pantoprazole from December 2004 to March 2005. Only patients receiving IV pantoprazole were included (n = 78). Data collected included demographics, indication and dosing of pantoprazole, admitting team (surgery vs. medicine), and risk factors for stress ulcers. RESULTS: Our study population had a mean age of 54 +/- 17 years and 62% were male. Overall, 45% (35/78) of patients receiving IV pantoprazole had an appropriate indication, and 19% (15/78) received the correct dose. Of the 78 patients, 43 (55%) were treated with pantoprazole for stress ulcer prophylaxis (SUP), and 35 (45%) patients were treated for GIB. We found that none of the 43 patients treated for SUP had an appropriate indication for pantoprazole, but all of the patients with GIB (35) had an appropriate indication. Of the 35 patients treated for GIB with pantoprazole, only 40% (14/35) received the correct dose. In all cases of incorrect dosing, the patients were underdosed. CONCLUSIONS: Pantoprazole is not being prescribed appropriately for stress ulcer prophylaxis in our patient population. Even in patients appropriately receiving pantoprazole the majority were prescribed an incorrect dose. Appropriate indications and dosing of pantoprazole could eliminate the shortages seen at our institution.
机译：背景：近年来，质子泵抑制剂的使用迅速增加。我们的机构最近几次出现IV潘托拉唑短缺的情况，每次持续7-10天。我们研究的目的是评估IV潘托拉唑的住院患者使用情况。根据现有文献，我们假设住院的上消化道出血（GIB）或有可能发生应激性溃疡的患者不适当地接受了静脉输注的潘托拉唑。方法：这是一项回顾性研究，从2004年12月至2005年3月，对165名连续被确定为接受pan托拉唑的住院患者进行了回顾性研究。仅纳入了接受静脉注射pan托拉唑的患者（n = 78）。收集的数据包括人口统计资料，of托拉唑的适应症和用药剂量，入院团队（手术与药物）以及应激性溃疡的危险因素。结果：我们的研究人群的平均年龄为54 +/- 17岁，其中62％为男性。总体而言，接受静脉注射pan托拉唑的患者中有45％（35/78）有适当的适应症，而有19％（15/78）的患者接受了正确的剂量。在78例患者中，有43例（55％）接受了pantoprazole预防应激性溃疡（SUP），而35例（45％）的患者接受了GIB治疗。我们发现接受SUP治疗的43例患者中没有一个对潘托拉唑有适当的适应症，但是所有GIB患者（35）都有一个适当的适应症。在用pan托拉唑治疗GIB的35例患者中，只有40％（14/35）接受了正确的剂量。在所有剂量不正确的情况下，患者的剂量均不足。结论：在我们的患者人群中，Pan托拉唑的处方不足以预防应激性溃疡。即使在适当地接受pan托拉唑的患者中，大多数人仍被处方不正确的剂量。适当的适应症和剂量的azole托拉唑可以消除我们机构中出现的短缺。

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