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首页> 外文期刊>Surgical Endoscopy >Laparoscopic sleeve gastrectomy with ileal transposition (SGIT): A new surgical procedure as effective as gastric bypass for weight control in a porcine model.
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Laparoscopic sleeve gastrectomy with ileal transposition (SGIT): A new surgical procedure as effective as gastric bypass for weight control in a porcine model.

机译：带回肠移位的腹腔镜袖胃切除术（SGIT）：一种新的外科手术方法，与猪胃旁路术一样有效，可控制猪模型中的体重。

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INTRODUCTION: Bariatric surgery has evolved into multiple forms in the last decades, combining food restriction and malabsorption. The aim of this study was to develop a new technique based on food restriction and early stimulation of the distal gut, thus maintaining the alimentary tract continuity. METHODS: Thirty-two Yorkshire pigs, weight 22.2 +/- 5.4 kg (mean +/- SD) were randomly assigned to four laparoscopic procedures: ileal transposition (IT, n = 8); sleeve gastrectomy with ileal transposition (SGIT, n = 8); Roux-en-Y gastric bypass (GBP, n = 8); sham operation (SHAM, n = 8). Firing 45-mm linear staplers over a 60-F bougie, resecting the greater curvature and fundus, constituted a sleeve gastrectomy. Ileal transposition was performed by isolating a 100-cm ileal segment proximal to the ileocecal valve and by dividing the proximal jejunum 15 cm distal to the ligament of Treitz and performing re-anastomosis. Gastric bypass consisted of creating a proximal gastric pouch and a 300 cm alimentary limb. Sham operation was performed by bowel transections and re-anastomosis in the ileum and proximal jejunum together with gastrotomy and closure. Animals were evaluated weekly for weight increase and food intake. We performed a logistic regression analysis to compare weight progression curves, and analysis of variance (ANOVA) and Bonferroni (Dunn) tests to detect differences in weight and food intake. RESULTS: We observed significant differences in mean weight after 18 weeks between SGIT (30.9 +/- 13.4 kg) and SHAM (72.5 +/- 10.7 kg) (p = 0.0002), and GBP (28.6 +/- 2.5 kg) and SHAM (p = 0.0001), and IT (56.1 +/- 13.4 kg) and SHAM (p = 0.0081). No differences were observed between RYGB and SGIT. We also observed significant differences in food intake (grams per day) in the third month between SGIT (1668 +/- 677 g) versus SHAM (3252 +/- 476 g) (p = 0.0006), and GBP (2011 +/- 565 g) versus SHAM (p = 0.039). No differences were observed in food intake between SGIT and GBP. CONCLUSION: SGIT proved to be as effective in the short term as GBP on weight progression with no bypass of the proximal gut.
机译：简介：减肥手术在过去的几十年中已发展成为多种形式，将饮食限制和吸收不良结合在一起。这项研究的目的是开发一种基于食物限制和早期刺激远端肠胃的新技术，从而保持消化道的连续性。方法：将32只约克郡猪（体重22.2 +/- 5.4 kg，平均+/- SD）随机分配至四种腹腔镜手术程序：回肠换位术（IT，n = 8）;带回肠移位的袖式胃切除术（SGIT，n = 8）; Roux-en-Y胃旁路术（GBP，n = 8）;假操作（SHAM，n = 8）。在60楼的炮塔上开火45毫米线性订书机，切除较大的曲率和眼底，构成了袖式胃切除术。通过隔离回盲瓣近端的100 cm回肠段，将Treje韧带远端的空肠近端分开15 cm并进行再吻合术，进行回肠移位。胃旁路术包括建立胃近端袋和300厘米消化肢。通过肠横断和在回肠和空肠近端再吻合，并进行胃切开术和闭合术，进行假手术。每周评估动物的体重增加和食物摄入。我们进行了逻辑回归分析以比较体重变化曲线，并进行了方差分析（ANOVA）和Bonferroni（Dunn）测试以检测体重和食物摄入的差异。结果：我们观察到SGIT（30.9 +/- 13.4 kg）和SHAM（72.5 +/- 10.7 kg）（p = 0.0002），GBP（28.6 +/- 2.5 kg）和SHAM在18周后的平均体重有显着差异（p = 0.0001），IT（56.1 +/- 13.4 kg）和SHAM（p = 0.0081）。 RYGB和SGIT之间未观察到差异。我们还观察到SGIT（1668 +/- 677克）与SHAM（3252 +/- 476克）（p = 0.0006）和GBP（2011 +/-）在第三个月的食物摄入量（克/天）之间存在显着差异565 g）与SHAM（p = 0.039）。 SGIT和GBP之间的食物摄入量没有差异。结论：SGIT在短期内被证明与GBP一样有效，在体重发展方面没有绕过近端肠道。

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