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首页> 外文期刊>Surgical Endoscopy >Assessment of the afferent vagal nerve in patients with gastroesophageal reflux.
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Assessment of the afferent vagal nerve in patients with gastroesophageal reflux.

机译：胃食管反流患者的迷走神经传入评估。

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摘要

BACKGROUND: The objective of this study was to assess the integrity of the vagal nerve afferent pathways in patients with gastroesophageal reflux disease (GERD). METHODS: Seven GERD patients (4 males and 3 females, mean age 39 +/- 8 years) were studied. Twelve healthy volunteers (11 males and 1 female, mean age 32 +/- 8 years) were used as the control group. Cortical evoked potentials were measured. Electrical stimulation of the esophageal mucosa was performed through a custom-built device. Latencies and N2/P2 amplitude were measured. RESULTS: Reproducible cortical evoked potentials were obtained from all subjects. The stimulation threshold for GERD patients to electrical esophageal stimulation was 5.1 +/- 1.5 mA compared to 7.8 +/- 2.0 mA in healthy volunteers (p <0.05). There was no difference in peak latencies or N2/P2 amplitude between GERD patients and controls. CONCLUSIONS: GERD patients have a normal vagal nerve function, but they exhibit a decreased threshold for esophageal perception. The mechanism responsible for increased esophageal sensitivity observed in GERD patients is still undetermined and warrants further study.
机译：背景：这项研究的目的是评估胃食管反流病（GERD）患者的迷走神经传入通路的完整性。方法：研究了7例GERD患者（男4例，女3例，平均年龄39 +/- 8岁）。十二名健康志愿者（男性11名，女性1名，平均年龄32 +/- 8岁）被用作对照组。测量皮层诱发电位。通过定制设备对食道粘膜进行电刺激。测量潜伏期和N2 / P2振幅。结果：从所有受试者获得可再现的皮层诱发电位。 GERD患者对食管电刺激的刺激阈值为5.1 +/- 1.5 mA，而健康志愿者为7.8 +/- 2.0 mA（p <0.05）。 GERD患者和对照组之间的峰值潜伏期或N2 / P2振幅没有差异。结论：GERD患者的迷走神经功能正常，但食管知觉阈值降低。仍未确定导致GERD患者食管敏感性增加的机制，有待进一步研究。

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