Assessment of cyclin D1 overexpression as a prognostic factor in soft tissue sarcomas: role of laparoscopy and core needle biopsy.

Musella M; Fazioli F; Lombardi S; Servodio CI; De Martino C; Iacono V; Cigala F; Jovino R

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Assessment of cyclin D1 overexpression as a prognostic factor in soft tissue sarcomas: role of laparoscopy and core needle biopsy.

机译：评估细胞周期蛋白D1过表达作为软组织肉瘤的预后因素：腹腔镜检查和穿刺活检的作用。

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BACKGROUND: This study was designed to test cyclin D1 as a prognostic marker in patients with soft tissue sarcomas (STS), and to evaluate the usefulness of laparoscopy for determining cyclin D1 overexpression. METHODS: The records of 62 patients with STS were collected: 28 with retroperitoneal STS (RSTS) and 34 with extremity STS (ESTS). A total of 51 patients underwent surgical resection, whereas 11 did not undergo surgery because of advanced tumor stage. Preoperative-intraoperative laparoscopic staging was performed for patients judged to be resectable at preoperative imaging. RESULTS: Cyclin D1 was overexpressed in 30 (58.8%) of 51 resected patients and in 10 (90.9%) of 11 nonresected patients. Laparoscopy avoided unnecessary laparotomy in 9 (32.1%) of 28 RSTS patients. CONCLUSIONS: High tumor grade, positive surgical margins, local recurrence, distant metastases, and cyclin D1 overexpression were related to poor survival. Multivariate analysis demonstrated cyclin D1 to be the only independent factor. Laparoscopy was shown to be useful for avoiding useless laparotomies.

机译：背景：这项研究旨在测试细胞周期蛋白D1作为软组织肉瘤（STS）患者的预后指标，并评估腹腔镜检查确定细胞周期蛋白D1过表达的有效性。方法：收集62例STS患者的记录：28例腹膜后STS（RSTS）和34例四肢STS（ESTS）。共有51例患者接受了手术切除，而11例由于晚期肿瘤未进行手术。对术前影像学可切除的患者进行术前腹腔镜分期。结果：Cyclin D1在51例切除的患者中有30（58.8％）和11例未切除的患者中的10（90.9％）过表达。腹腔镜检查避免了28例RSTS患者中的9例（32.1％）进行不必要的剖腹手术。结论：高肿瘤分级，手术切缘阳性，局部复发，远处转移和细胞周期蛋白D1过表达与不良的生存率有关。多变量分析表明，cyclin D1是唯一的独立因素。腹腔镜检查对于避免无用的腹腔镜手术是有用的。

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《Surgical Endoscopy》 |2005年第8期|共5页
作者
Musella M; Fazioli F; Lombardi S; Servodio CI; De Martino C; Iacono V; Cigala F; Jovino R;
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正文语种 eng
中图分类外科学;
关键词
cyclin D; overexpress; Laparoscopy; Sequence Tagged Sites; Ions; 腹腔镜检查; 序列靶位点; 离子;

机译：cyclin D;overexpress;Laparoscopy;Sequence Tagged Sites;Ions;腹腔镜检查;序列靶位点;离子;

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1. Assessment of cyclin D1 overexpression as a prognostic factor in soft tissue sarcomas: role of laparoscopy and core needle biopsy. [J] . Musella M, Fazioli F, Lombardi S, Surgical Endoscopy . 2005,第8期

机译：评估细胞周期蛋白D1过表达作为软组织肉瘤的预后因素：腹腔镜检查和穿刺活检的作用。
2. Aminopeptidase N (CD13): Expression, Prognostic Impact, and Use as Therapeutic Target for Tissue Factor Induced Tumor Vascular Infarction in Soft Tissue Sarcoma [J] . Torsten Kessler, Ariane Baumeier, Caroline Brand, Translational Oncology . 2018,第6期

机译：氨肽酶N（CD13）：表达，预后影响和用作组织因子诱导的软组织肉瘤肿瘤血管梗塞的治疗靶标
3. Prognostic factors for soft tissue sarcoma patients with lung metastases only who are receiving first-line chemotherapy An exploratory, retrospective analysis of the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) [J] . Lindner Lars H., Litiere Saskia, Sleijfer Stefan, International Journal of Cancer =: Journal International du Cancer . 2018,第12期

机译：软组织肉瘤患者肺转移患者的预后因素仅接受一线化疗，探讨欧洲癌症软组织和骨肉瘤组研究和治疗组织的探索性，回顾性分析（EORTC-STBSG）
4. Prognosis factors in muscle-skeletal tumors (Osteosarcomas and soft tissue sarcomas) [C] . MILENA ADINA MAN, DANA ALEXANDRESCU, DANA BADAU WSEAS International Conferences . 2009

机译：肌肉骨骼肿瘤预后因素（骨肉瘤和软组织肉瘤）
5. Prognostic Role of Rb p16 Cyclin D1 Proteins in Soft Tissue Sarcomas [O] . Byoung Yong Shim, Jinyoung Yoo, Yeon-Soo Lee, 2010

机译：Rbp16Cyclin D1蛋白在软组织肉瘤中的预后作用
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机译：队列研究c-erbB-2和细胞周期蛋白D1过表达，p53突变和/或蛋白质积累，以及从良性乳腺疾病进展到乳腺癌的风险;和创建良性乳腺组织

Assessment of cyclin D1 overexpression as a prognostic factor in soft tissue sarcomas: role of laparoscopy and core needle biopsy.

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