...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Surgical Endoscopy >Randomized blinded trial comparing the cardiopulmonary effects of NOTES with standard laparoscopy in a porcine survival model.
【24h】

Randomized blinded trial comparing the cardiopulmonary effects of NOTES with standard laparoscopy in a porcine survival model.

机译：在猪生存模型中比较NOTES与标准腹腔镜检查对心肺功能的随机盲试验。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Anecdotal reports of natural orifice translumenal endoscopic surgery (NOTES) procedures in patients are emerging. Whether the new procedure is truly less invasive is not known. We compared perioperative cardiopulmonary parameters during NOTES with standard laparoscopy. METHODS: Twelve swine were randomized to transgastric peritoneoscopy with air or diagnostic laparoscopy with CO(2). Cardiopulmonary parameters were invasively monitored. Animals were survived for 14 days. Data were analyzed by an investigator blinded to the procedure performed. Treatments were contrasted on the mean outcome using a repeated measures linear model. RESULTS: All experiments were successfully completed. No gastric leak or peritonitis resulted. Two hundred and fifty cubic centimeters of saline irrigation was adequate to decrease gastric contamination. Respiratory compromise requiring desufflation resulted in two laparoscopy and one endoscopy animal. Mean arterial oxygen saturation remained at baseline for the NOTES group and decreased by 1.5 +/- 1.5% in the laparoscopic group (p 0.001). Mean arterial pH dropped significantly lower in the laparoscopy versus the NOTES group (-0.09 +/- 0.06 versus -0.05 +/- 0.05, p = 0.01). Mean systolic blood pressure (Sbp) in both groups remained unchanged from the respective baseline (p = 0.45). Mean diastolic blood pressure (Dbp) showed a mean difference of 19 +/- 1.5 mmHg between the groups (p 0.001), increasing from baseline for the laparoscopy group and decreasing significantly from baseline in the NOTES group (+2.4 +/- 12.5 versus -6.1 +/- 7.0 mmHg, p 0.001). Mean heart rate increased significantly from baseline in the laparoscopy group compared to the NOTES group (15.0 +/- 23.4 versus 3.8 +/- 19.0 bpm, p = 0.004). A widening pulse pressure resulted in the NOTES group compared to the laparoscopy group (p 0.001). The mean bladder pressure was 14.6 +/- 8.0 cmH(2)O in the laparoscopy group compared to 7.1 +/- 7.1 cm H(2)O the NOTES group (p 0.001). CONCLUSION: Significant differences in measured but not clinically apparent cardiopulmonary parameters were encountered. The difference in insufflation gas, different vagal or catecholamine response may be contributing to these findings.
机译：背景：有关患者自然孔腔内镜手术（NOTES）程序的传闻不断。目前尚不清楚新手术是否真正具有较小的侵入性。我们将NOTES期间的围手术期心肺参数与标准腹腔镜检查进行了比较。方法：将十二只猪随机分配至经空气的经胃腹膜镜检查或采用CO（2）的诊断性腹腔镜检查。侵入性监测心肺参数。动物存活14天。数据由不了解所执行程序的研究人员进行分析。使用重复测量线性模型将治疗与平均结局进行对比。结果：所有实验均成功完成。没有导致胃漏或腹膜炎。 250立方厘米的盐水冲洗足以减少胃部污染。需要通气的呼吸困难导致了两只腹腔镜检查和一只内窥镜检查动物。 NOTES组的平均动脉血氧饱和度保持在基线水平，而腹腔镜组的平均动脉血氧饱和度下降1.5 +/- 1.5％（p <0.001）。与NOTES组相比，腹腔镜检查中的平均动脉pH值明显降低（-0.09 +/- 0.06对-0.05 +/- 0.05，p = 0.01）。两组的平均收缩压（Sbp）与各自的基线相比均保持不变（p = 0.45）。平均舒张压（Dbp）显示两组之间的平均差异为19 +/- 1.5 mmHg（p <0.001），腹腔镜检查组的基线水平较基线升高，而NOTES组的基线水平显着降低（+2.4 +/- 12.5）相对于-6.1 +/- 7.0 mmHg，p <0.001）。与NOTES组相比，腹腔镜检查组的平均心率从基线显着增加（15.0 +/- 23.4与3.8 +/- 19.0 bpm，p = 0.004）。与腹腔镜检查组相比，NOTES组的脉冲压增高（p <0.001）。腹腔镜检查组的平均膀胱压力为14.6 +/- 8.0 cmH（2）O，而NOTES组的平均膀胱压力为7.1 +/- 7.1 cm H（2）O（p <0.001）。结论：在测得的心肺参数方面存在显着差异，但在临床上没有明显差异。吹入气体的差异，迷走神经或儿茶酚胺的反应不同可能是这些发现的原因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号