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首页> 外文期刊>Surgical Endoscopy >Protection of trocar sites from gallbladder cancer implantation by sodium hyaluronate shill carboxymethylcellulose-based bioresorbable membrane (Seprafilm) in a murine (correction of nurine) model.
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Protection of trocar sites from gallbladder cancer implantation by sodium hyaluronate shill carboxymethylcellulose-based bioresorbable membrane (Seprafilm) in a murine (correction of nurine) model.

机译：透明质酸钠基于羧甲基纤维素的生物可吸收膜（Seprafilm）在鼠（尿液校正）模型中保护套管针部位免受胆囊癌植入。

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BACKGROUND: The risk of port site metastasis in laparoscopic surgery for cancer patients is a problem that has yet to be resolved. We examined the protective effect of a sodium hyaluronate-based bioresorbable membrane (Seprafilm) on tumor cell implantation at laparoscopic trocar sites. METHODS: Four 2-mm trocar sites were created in nude mice, and the peritoneal wounds were covered with different-sized pieces of Seprafilm. The protective effect of Seprafilm on the implantation of GB-d1 (a human gallbladder cancer cell line) at the trocar sites was assessed after 7 days. In addition, the effects of sodium hyaluronate and Seprafilm on the growth and motility of GB-d1 were examined in vitro. RESULTS: Seprafilm significantly decreased the incidence of implantation compared with the control group. Histologically, Seprafilm was observed on days 1 and 3, as a sheet of gel that covered the injured peritoneum and muscle layer. In an invasion assay using Seprafilm, no cells were found to infiltrate through the gel sheet. CONCLUSION: Seprafilm protects peritoneal wounds by physically covering the injured peritoneum. Therefore, if Seprafilm were attached to the injured peritoneum after laparoscopic surgery for cancer patients, it might reduce port site metastasis.
机译：背景：腹腔镜手术中癌症患者发生端口部位转移的风险是一个尚未解决的问题。我们检查了基于透明质酸钠的生物可吸收膜（Seprafilm）对腹腔镜套管针部位肿瘤细胞植入的保护作用。方法：在裸鼠中创建4个2毫米的套管针部位，并用不同大小的Seprafilm片覆盖腹膜伤口。 7天后评估Seprafilm对在套管针部位植入GB-d1（人胆囊癌细胞系）的保护作用。此外，体外检查了透明质酸钠和Seprafilm对GB-d1生长和运动的影响。结果：与对照组相比，Seprafilm显着降低了植入率。组织学上，在第1天和第3天观察到Seprafilm，它是一块覆盖受伤的腹膜和肌肉层的凝胶。在使用Seprafilm的侵袭分析中，未发现任何细胞渗入凝胶片。结论：Seprafilm通过物理覆盖受伤的腹膜来保护腹膜伤口。因此，对于癌症患者，如果在腹腔镜手术后将Seprafilm贴在受伤的腹膜上，可能会减少端口部位转移。

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