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首页> 外文期刊>Surgical Endoscopy >Strength of tissue attachment to mesh after ventral hernia repair with synthetic composite mesh in a porcine model.
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Strength of tissue attachment to mesh after ventral hernia repair with synthetic composite mesh in a porcine model.

机译：在猪模型中使用合成复合网修复腹疝后组织附着到网的强度。

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BACKGROUND: A prospective animal study involving 12 female swine aimed to measure the strength of tissue attachment to composite mesh at various time points after laparoscopic ventral hernia repair in a porcine model. METHODS: Each animal had two 10 x 16-cm sheets of polypropylene/expanded polytetrafluoroethylene (ePTFE) composite mesh laparoscopically affixed to the abdominal wall with a helical tacking device. No transfascial sutures were used. The animals were euthanized 2, 4, 6, and 12 weeks after surgery, and abdominal walls were resected en bloc with the patches. Each patch was cut into 2 x 7-cm strips, and each strip was independently analyzed. The strength of the tissue attachment to the mesh was measured using a servohydraulic tensile testing frame. The abdominal wall was peeled from the mesh, and the transverse, or "lap-shear" force was recorded. Data are reported as mean force in pounds. RESULTS: The mean lap-shear force was 0.83 +/- 0.06 lbs at 2 weeks, 1.06 +/- 0.07 lbs at 4 weeks, 0.88 +/- 0.08 lbs at 6 weeks, and 1.13 +/- 0.07 lbs at 12 weeks. The mean force was higher at 12 weeks than at 2 weeks (p < 0.05). No other periods were significantly different from any other. CONCLUSIONS: The findings demonstrate that the majority of tissue ingrowth and strength has occurred by 2 weeks after laparoscopic placement of a composite hernia prosthesis. Strength very gradually increases until 12 weeks after surgery. This has clinical implications for human ventral hernia repair. Further study is needed to evaluate the necessity of transfascial sutures for securing polypropylene-based prostheses to the abdominal wall during ventral hernia repair.
机译：背景：一项涉及12只雌性猪的前瞻性动物研究，旨在在猪模型中腹腔镜腹侧疝修补术后的不同时间点，测量组织在复合网片上的附着强度。方法：每只动物有两个10 x 16厘米的聚丙烯/膨体聚四氟乙烯（ePTFE）复合网片，腹腔镜通过螺旋固定装置固定在腹壁上。没有使用经筋膜缝合。手术后第2、4、6和12周对动物实施安乐死，并用贴片整块切除腹壁。将每个贴片切成2 x 7厘米的条，并分别分析每个条。使用伺服液压拉伸测试架测量组织附着在网上的强度。从网上剥离腹壁，并记录横向或“搭接剪切”力。数据报告为以磅为单位的平均力。结果：平均搭接剪切力在第2周时为0.83 +/- 0.06磅，在第4周时为1.06 +/- 0.07磅，在第6周时为0.88 +/- 0.08磅，在第12周时为1.13 +/- 0.07磅。 12周时的平均力量高于2周时的平均力量（p <0.05）。其他期间均无明显差异。结论：研究结果表明，腹腔镜下放置复合疝气假体后2周，大部分组织向内生长和生长。直到手术后12周强度才逐渐增加。这对人腹疝修补有临床意义。需要进行进一步的研究，以评估在腹部疝气修复过程中采用经筋膜缝合将聚丙烯基假体固定在腹壁上的必要性。

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