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Laparoscopic cholecystectomy in children with chronic hemolytic anemia. Is the outcome related to the timing of the procedure?

机译:小儿慢性溶血性贫血的腹腔镜胆囊切除术。结果与手术时间有关吗?

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BACKGROUND: The aim of this study was to evaluate whether the outcome in children with chronic hemolytic anemia (CHA) and cholelithiasis undergoing laparoscopic cholecystectomy (LC) is related to the operation timing. METHODS: From June 1995 to December 2004, 46 children with CHA were referred to our division of surgery for cholelithiasis. All 46 children were asymptomatic at the time of the first visit, and an elective LC was proposed to all of them before the onset of symptoms. The operation was accepted in the period of study by 24 children and refused by 22. The patients were divided into three groups (group A, asymptomatic; group B, symptomatic; and group C, emergency admitted) depending on clinical presentation and operation timing, and the respective outcomes were compared. RESULTS: Elective LC in asymptomatic children (group A) is safe with no major complications reported. In children who refused surgery (groups B and C), we observed four sickle cell crises, four acute cholecystitis, and two choledocholithiasis, and all these complications were related to waiting. Two sickle cell crises occurred in symptomatic children waiting for surgery during biliary colic. The risk of emergency admission in children with cholelithiasis and CHA awaiting surgery was found to be high: 28% of the children admitted in emergency after a mean of 32 months (range, 22-36). Morbidity rate and postoperative stay increased when children with hemoglobinopathies underwent emergency LC. CONCLUSIONS: Elective LC should be the gold standard in children with CHA and asymptomatic cholelithiasis in order to prevent the potential complications of cholecystitis and choledocholithiasis, which lead to major risks, discomfort, and longer hospital stay.
机译:背景:本研究的目的是评估接受腹腔镜胆囊切除术(LC)的慢性溶血性贫血(CHA)和胆石症患儿的结局是否与手术时机有关。方法:1995年6月至2004年12月,将46例CHA患儿转入我们的胆石症手术科。初次就诊时,所有46名儿童均无症状,并且在症状发作之前对所有儿童提出了选择性LC。在研究期间,有24名儿童接受了手术,但有22名儿童拒绝了手术。根据临床表现和手术时间,将患者分为三组(A组无症状; B组有症状; C组急诊),并比较了各自的结果。结果:无症状儿童(A组)的选择性LC是安全的,没有重大并发症的报道。在拒绝手术的儿童(B和C组)中,我们观察到四次镰状细胞危机,四次急性胆囊炎和两次胆总管结石症,所有这些并发症均与等待有关。有症状的儿童在胆绞痛期间等待手术的过程中发生了两次镰状细胞危机。发现患有胆石症和等待手术的CHA的儿童紧急入院的风险很高:平均32个月后(22-36岁),紧急入院的儿童为28%。当患有血红蛋白病的儿童接受紧急LC时,发病率和术后住院时间增加。结论:择期LC应成为CHA和无症状性胆石症儿童的金标准,以防止可能导致严重危险,不适和更长住院时间的胆囊炎和胆石症的潜在并发症。

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