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Novel technique for in situ cold perfusion in laparoscopic partial nephrectomy.

机译:腹腔镜部分肾切除术中原位冷灌注的新技术。

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摘要

BACKGROUND: Following clamping of the renal hilus, warm ischemia is an issue in laparoscopic partial nephrectomy. If ischemia longer than 30 min is anticipated, special protective measures are needed. The aim of this study was to develop a solely laparoscopic technique for in situ cold perfusion of kidneys during laparoscopic partial nephrectomy to increase the tolerance of renal parenchyma to ischemic damage in a porcine model. METHODS: Six animals were used in this study. We tried to develop a technique that allowed us to cannulate the renal artery, introduce a catheter to perform an in situ cold perfusion and-the most important feature-secure the catheter throughout the laparoscopic partial nephrectomy. RESULTS: A modified laparoscopic vascular bulldog clamp was ultimately ideal to fulfil expectations. In five pigs, a successful partial nephrectomy in in situ perfusion was performed. The median warm ischemia time, starting from occlusion of the renal artery and vein to the commencement of cold perfusion, was 130 s (range 75-165 s). The subsequent median cold ischemia time in which a partial nephrectomy was simulated was 42 min (range 26-52 min). CONCLUSIONS: The newly developed technique expands the armamentarium of the urologist in laparoscopic partial nephrectomy, if the anticipated time of ischemia exceeds 30 min and renal hypothermia is indicated.
机译:背景:夹住肾盂后,温暖的缺血是腹腔镜部分肾切除术中的一个问题。如果预计缺血时间超过30分钟,则需要采取特殊的保护措施。这项研究的目的是开发一种腹腔镜技术,用于在腹腔镜部分肾切除术中对肾脏进行原位冷灌注,以提高猪模型中肾实质对缺血性损伤的耐受性。方法:本研究使用了六只动物。我们试图开发一种技术,使我们能够插管肾动脉,引入导管以进行原位冷灌注,并且最重要的功能是在整个腹腔镜部分肾切除术中确保导管的安全。结果:改良的腹腔镜血管牛头犬钳最终是理想的理想选择。在五只猪中,成功进行了局部肾切除术。从阻塞肾动脉和静脉到开始冷灌注的中位温暖缺血时间为130 s(范围75-165 s)。随后的模拟部分肾切除术的冷缺血中位时间为42分钟(范围为26-52分钟)。结论:如果预期的局部缺血时间超过30分钟并提示有肾低温,则新开发的技术可扩大腹腔镜部分肾切除术中泌尿科医师的武器库。

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