...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Surgical Endoscopy >A lightweight, partially absorbable mesh (Ultrapro) for endoscopic hernia repair: experimental biocompatibility results obtained with a porcine model.
【24h】

A lightweight, partially absorbable mesh (Ultrapro) for endoscopic hernia repair: experimental biocompatibility results obtained with a porcine model.

机译：用于内窥镜疝气修复的轻巧，可部分吸收的网片（Ultrapro）：通过猪模型获得的实验生物相容性结果。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: A meticulous surgical technique, a mesh of adequate dimensions, and use of a mesh with good biocompatibility properties are decisively important for minimizing the development of recurrences after endoscopic hernia repair surgery. Mesh "shrinkage" is a function of the mesh's biocompatibility, that is, the properties of the mesh. Large-pore, lightweight polypropylene meshes possess the best biocompatibility, and the newly developed meshes meet these requirements. METHODS: Using a totally extraperitoneal technique in an experimental animal model, 10 domestic pigs were implanted with a lightweight, large-pore polypropylene mesh containing an absorbable component consisting of poliglecaprone (Ultrapro). After a period of 91 days, diagnostic laparoscopy followed by explantation of the specimens for macroscopic, histologic, and immunohistochemical evaluation was performed. RESULTS: The mean mesh shrinkage was a mere 1.9%. The partial volume of the inflammatory cells was a low 15.8%. The markers of cell turnover, namely Ki67 and the apoptosis index, were, at 5.8 and 2.1, respectively, also very low. The extracellular matrix showed a low value of transforming growth factor-beta (TGF-beta) (50.8). The mean value of collagen 1 was 136.9. CONCLUSIONS: As a result of its good biocompatibility and elastic properties, the lightweight, large-pore Ultrapo mesh showed only a very slight tendency to "shrink." This renders it extremely well suited for clinical use in hernia repair surgery, and its minimal shrinkage characteristic should help in achieving low complication and recurrence rates.
机译：背景：细致的手术技术，适当尺寸的网片以及具有良好生物相容性的网片的使用对于将内窥镜疝气修补手术后复发的发生率降至最低至关重要。网格的“收缩率”是网格的生物相容性（即网格的属性）的函数。大孔，轻质的聚丙烯网具有最佳的生物相容性，新开发的网可满足这些要求。方法：在实验动物模型中使用完全腹膜外技术，向10头家猪植入了轻巧的大孔聚丙烯网，其中包含聚丙烯酰胺（Ultrapro）。 91天后，进行诊断性腹腔镜检查，然后移出标本进行宏观，组织学和免疫组化评估。结果：平均网孔收缩率仅为1.9％。炎性细胞的部分体积低至15.8％。细胞更新的标志物，即Ki67和凋亡指数，分别为5.8和2.1，也非常低。细胞外基质显示较低的转化生长因子-β（TGF-β）（50.8）值。胶原蛋白1的平均值为136.9。结论：由于其良好的生物相容性和弹性，轻巧的大孔Ultrapo网眼仅表现出很小的“收缩”趋势。这使其非常适合疝修补术的临床应用，并且其最小的收缩特性应有助于实现较低的并发症和复发率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号